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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Vaccinium

  • This study investigated the mechanism(s) by which three flavonoid-enriched fractions from lowbush blueberry (Vaccinium angustifolium) down-regulate MMP activity in DU145 human prostate cancer cells [1].

High impact information on Vaccinium

  • We have studied the expression of flavonoid biosynthesis genes during the development of bilberry (Vaccinium myrtillus) fruit in relation to the accumulation of anthocyanins, proanthocyanidins, and flavonols in wild berries and in color mutants of bilberry [2].
  • In this study, we investigated short- as well as long-term plant nitrogen uptake by Deschampsia flexuosa, Picea abies and Vaccinium myrtillus from 15NO3-, 15NH4+ and (U-13C, 15N) arginine, glycine or peptides [3].
  • The anthocyanidin and ethyl acetate extracts of the four Vaccinium species were either inactive or relatively weak inhibitors of ODC activity [4].
  • Antioxidant activity in lingonberries (Vaccinium vitis-idaea L.) and its inhibitory effect on activator protein-1, nuclear factor-kappaB, and mitogen-activated protein kinases activation [5].
  • Radical scavenging and antioxidant activities of Vaccinium berry fractions were attributable to the their composition of catechins and procyanidins [6].

Biological context of Vaccinium


Anatomical context of Vaccinium

  • The effects of Vaccinium Myrtillus anthocyanosides (Myrtocyan, VMA; CAS 84082-34-8) on arteriolar vasomotion were assessed in cheek pouch microcirculation of anesthetized hamsters and in skeletal muscle microvasculature of unanesthetized hamster skin fold window preparation [9].

Associations of Vaccinium with chemical compounds

  • Phenolics from the American cranberry (Vaccinium macrocarpon) were fractionated into a series of proanthocyanidins and other flavonoid compounds by vacuum chromatography on a hydrophilic, porous polyvinylic gel permeation polymer [10].
  • After 18 min of heating at 190 degrees C, between 17 and 46% of the resveratrol had degraded in the various Vaccinium species [11].
  • This broader soil adaptation in V. arboreum may be related to increased efficiency of iron or nitrate uptake compared with the cultivated Vaccinium species [12].
  • Antimicrobial activity of tannin components from Vaccinium vitis-idaea L [13].
  • A new ortho-benzoyloxyphenyl acetic acid ester, called vaccihein A (1), was isolated from the fruit of rabbiteye blueberry (Vaccinium ashei) [14].

Gene context of Vaccinium

  • Effective separation of potent antiproliferation and antiadhesion components from wild blueberry (Vaccinium angustifolium Ait.) fruits [15].
  • Effect of ammonium and nitrate on ferric chelate reductase and nitrate reductase in Vaccinium species [12].
  • In the course of finding Korean natural products with acetylcholinesterase (AChE) inhibitory activity, we found that a methanolic extract of the twigs of Vaccinium oldhami significantly inhibited AChE [16].
  • The efficacy of pruning methods for managing blueberry stem galls caused by the chalcid wasp, Hemadas nubilipennis (Ashmead), was studied in five commercial lowbush blueberry (Vaccinium angustifolium Aiton) fields in Nova Scotia, Canada, between October 1999 and May 2000 [17].
  • Several monitoring techniques were evaluated for their effectiveness, based on the highest mean captures of cranberry tipworm, Dasineura oxycoccana (Johnson), in detecting D. oxycoccana in rabbiteye, Vaccinium ashei Reade, and southern highbush, V. corymbosum L. x V. darrowi Camp, blueberry plantings [18].

Analytical, diagnostic and therapeutic context of Vaccinium

  • In order to screen the active constituents of Vaccinium vitis-idaea L., the compounds absorbed into the rat blood after oral administration of ethanol extract of the stems and leaves of V. vitis-idaea (EEV) have been analyzed [19].


  1. Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. Matchett, M.D., MacKinnon, S.L., Sweeney, M.I., Gottschall-Pass, K.T., Hurta, R.A. J. Nutr. Biochem. (2006) [Pubmed]
  2. Expression of genes involved in anthocyanin biosynthesis in relation to anthocyanin, proanthocyanidin, and flavonol levels during bilberry fruit development. Jaakola, L., Määttä, K., Pirttilä, A.M., Törrönen, R., Kärenlampi, S., Hohtola, A. Plant Physiol. (2002) [Pubmed]
  3. Nitrogen acquisition from inorganic and organic sources by boreal forest plants in the field. Persson, J., Högberg, P., Ekblad, A., Högberg, M.N., Nordgren, A., Näsholm, T. Oecologia (2003) [Pubmed]
  4. In vitro anticancer activity of fruit extracts from Vaccinium species. Bomser, J., Madhavi, D.L., Singletary, K., Smith, M.A. Planta Med. (1996) [Pubmed]
  5. Antioxidant activity in lingonberries (Vaccinium vitis-idaea L.) and its inhibitory effect on activator protein-1, nuclear factor-kappaB, and mitogen-activated protein kinases activation. Wang, S.Y., Feng, R., Bowman, L., Penhallegon, R., Ding, M., Lu, Y. J. Agric. Food Chem. (2005) [Pubmed]
  6. Catechins and procyanidins in berries of vaccinium species and their antioxidant activity. Määttä-Riihinen, K.R., Kähkönen, M.P., Törrönen, A.R., Heinonen, I.M. J. Agric. Food Chem. (2005) [Pubmed]
  7. Interspecific variation in anthocyanins, phenolics, and antioxidant capacity among genotypes of highbush and lowbush blueberries (Vaccinium section cyanococcus spp.). Kalt, W., Ryan, D.A., Duy, J.C., Prior, R.L., Ehlenfeldt, M.K., Vander Kloet, S.P. J. Agric. Food Chem. (2001) [Pubmed]
  8. Isoprene derivatives from the leaves and callus cultures of Vaccinium corymbosum var. bluecrop. Migas, P., Cisowski, W., Dembińska-Migas, W. Acta poloniae pharmaceutica. (2005) [Pubmed]
  9. Effects of Vaccinium Myrtillus anthocyanosides on arterial vasomotion. Colantuoni, A., Bertuglia, S., Magistretti, M.J., Donato, L. Arzneimittel-Forschung. (1991) [Pubmed]
  10. Composition of a chemopreventive proanthocyanidin-rich fraction from cranberry fruits responsible for the inhibition of 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity. Kandil, F.E., Smith, M.A., Rogers, R.B., Pépin, M.F., Song, L.L., Pezzuto, J.M., Seigler, D.S. J. Agric. Food Chem. (2002) [Pubmed]
  11. Resveratrol in raw and baked blueberries and bilberries. Lyons, M.M., Yu, C., Toma, R.B., Cho, S.Y., Reiboldt, W., Lee, J., van Breemen, R.B. J. Agric. Food Chem. (2003) [Pubmed]
  12. Effect of ammonium and nitrate on ferric chelate reductase and nitrate reductase in Vaccinium species. Poonnachit, U., Darnell, R. Ann. Bot. (2004) [Pubmed]
  13. Antimicrobial activity of tannin components from Vaccinium vitis-idaea L. Ho, K.Y., Tsai, C.C., Huang, J.S., Chen, C.P., Lin, T.C., Lin, C.C. J. Pharm. Pharmacol. (2001) [Pubmed]
  14. Antioxidant ortho-benzoyloxyphenyl acetic acid ester, vaccihein A, from the fruit of rabbiteye blueberry (Vaccinium ashei). Ono, M., Masuoka, C., Koto, M., Tateishi, M., Komatsu, H., Kobayashi, H., Igoshi, K., Ito, Y., Okawa, M., Nohara, T. Chem. Pharm. Bull. (2002) [Pubmed]
  15. Effective separation of potent antiproliferation and antiadhesion components from wild blueberry (Vaccinium angustifolium Ait.) fruits. Schmidt, B.M., Howell, A.B., McEniry, B., Knight, C.T., Seigler, D., Erdman, J.W., Lila, M.A. J. Agric. Food Chem. (2004) [Pubmed]
  16. Acetylcholinesterase inhibitors from the twigs of Vaccinium oldhami Miquel. Lee, J.H., Lee, K.T., Yang, J.H., Baek, N.I., Kim, D.K. Arch. Pharm. Res. (2004) [Pubmed]
  17. The influence of pruning on wasp inhabitants of galls induced by Hemadas nubilipennis Ashmead (Hymenoptera: Pteromalidae) on lowbush blueberry. Hayman, D.I., MacKenzie, K.E., Reekie, E.G. J. Econ. Entomol. (2003) [Pubmed]
  18. Techniques for monitoring cranberry tipworm (Diptera: Cecidomyiidae) in rabbiteye and southern highbush blueberries. Sarzynski, E.M., Liburd, O.E. J. Econ. Entomol. (2003) [Pubmed]
  19. Analysis and bioactive evaluation of the compounds absorbed into blood after oral administration of the extracts of Vaccinium vitis-idaea in rat. Wang, X., Sun, H., Fan, Y., Li, L., Makino, T., Kano, Y. Biol. Pharm. Bull. (2005) [Pubmed]
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