- Down regulation of high in normal-1 (HIN-1) is a frequent event in stage I non-small cell lung cancer and correlates with poor clinical outcome. Marchetti, A., Barassi, F., Martella, C., Chella, A., Salvatore, S., Castrataro, A., Mucilli, F., Sacco, R., Buttitta, F. Clin. Cancer Res. (2004)