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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Liver injury associated with the beta-interferons for MS: a comparison between the three products.

A population-based retrospective chart review of the biochemical liver tests of 844 patients with multiple sclerosis prescribed a beta-interferon (IFNbeta) product in British Columbia, Canada was performed between 1995 and 2001. Overall, 36.9% (243/659) of patients developed new elevations of alanine aminotransferase. All the IFNbetas caused elevated aminotransferase levels compared with pretreatment levels (p < 0.005) and were higher than reported in clinical trials. Their relative effect on aminotransferases can be approximated as IFNbeta-1b(subcutaneous [SC]) = IFNbeta-1a(SC) > IFNbeta-1a(IM).[1]

References

  1. Liver injury associated with the beta-interferons for MS: a comparison between the three products. Tremlett, H.L., Yoshida, E.M., Oger, J. Neurology (2004) [Pubmed]
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