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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Host factors and failure of interferon-alpha treatment in hepatitis C virus.

Failure of interferon-alpha (IFN-alpha) treatment in patients with chronic hepatitis C virus (HCV) infection is a challenging obstacle for clinical and experimental hepatology. Both viral and host factors have been implicated in reducing responsiveness to IFN-alpha therapy. The role of viral factors has been studied extensively and has been summarized in several review articles; however, much less attention has been paid to host factors. In this paper, we review evidence of host factor involvement in IFN-alpha treatment failure. We discuss possible underlying mechanisms responsible for these effects. Potential therapeutic strategies to enhance the effectiveness of IFN-alpha therapy for HCV are also proposed.[1]


  1. Host factors and failure of interferon-alpha treatment in hepatitis C virus. Gao, B., Hong, F., Radaeva, S. Hepatology (2004) [Pubmed]
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