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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
The discovery of structurally novel CCR1 antagonists derived from a hydroxyethylene peptide isostere template.
The present manuscript details the discovery and early fundamental structure-activity relationship studies involving compound 3, a novel hydroxyethylene peptide isostere derived molecule that provides micromolar inhibition of CCL3 binding to its receptor CCR1. Initial studies established this screening hit as a legitimate lead for further medicinal chemistry optimization.[1]
