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Chemical Compound Review

Polyviol     ethenol

Synonyms: Gelvatol, Gohsenol, Vinarole, alkenols, Alkotex, ...
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Disease relevance of POLYVINYL ALCOHOL


Psychiatry related information on POLYVINYL ALCOHOL


High impact information on POLYVINYL ALCOHOL


Chemical compound and disease context of POLYVINYL ALCOHOL


Biological context of POLYVINYL ALCOHOL


Anatomical context of POLYVINYL ALCOHOL


Associations of POLYVINYL ALCOHOL with other chemical compounds

  • Further comparisons suggest that resonance effects are between roughly 58% and 65% of the 26 kcal/mol calculated acidity enhancement of vinyl alcohol over methanol, and the remaining 42% to 35% are due to inductive effects [27].
  • Based on the results of in vitro and in vivo experiments, we have determined that the optimal material for the central transparent portion of a perforating keratoprosthesis is a polyvinyl alcohol copolymer hydrogel [28].
  • Segmental and complete hepatic artery embolization with Ivalon (polyvinyl alcohol) particles (0.25 to 1 mm) was performed in 12 dogs to evaluate hepatic function alterations and histopathological changes [25].
  • With PVA, a large amount of capillary formations occurred within the embolized arteries, whereas chitin particles and chitosan microspheres showed a lower rate of capillary formation [26].
  • On-chip capillary electrophoresis with uncoated and polyvinyl alcohol-coated glass channels in aqueous and nonaqueous dimethyl sulfoxide (DMSO) background electrolyte (BGE) solutions was applied in the separation of five amines derivatized with fluorescein-5-isothiocyanate [29].


  • An inhibitor, OM00-3, Glu-Leu-Asp-LeuAla-Val-Glu-Phe (where the asterisk represents the hydroxyethylene tansition-state isostere), designed from the consensus residues, was found to be the most potent inhibitor of memapsin 2 so far reported (K(i) of 3.1 x 10(-10) M) [30].
  • We have previously shown that angiogenesis, as reflected by fibrovascular invasion into subcutaneously implanted polyvinyl alcohol (PVA) sponges, is increased in SPARC-null mice (6-9 months of age) relative to their wild-type (WT) counterparts [31].
  • SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges [32].
  • To study the effects of insulin and insulin-like growth factor-I (IGF-I) on the development of bovine embryos, fertilized bovine embryos in vitro were cultured in a chemically defined, protein-free medium: modified synthetic oviduct fluid (mSOF) supplemented with lmg/ml polyvinyl alcohol [33].
  • The first potent inhibitors are based on the sequence of APP around the beta-secretase cleavage site EVNL/DAEF, with the scissile Leu-Asp amide bond being replaced by a hydroxyethylene transition state analogue isostere [34].

Analytical, diagnostic and therapeutic context of POLYVINYL ALCOHOL


  1. L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Vacca, J.P., Dorsey, B.D., Schleif, W.A., Levin, R.B., McDaniel, S.L., Darke, P.L., Zugay, J., Quintero, J.C., Blahy, O.M., Roth, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1. Chuang-Tsai, S., Sisson, T.H., Hattori, N., Tsai, C.G., Subbotina, N.M., Hanson, K.E., Simon, R.H. Am. J. Pathol. (2003) [Pubmed]
  3. Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection. Angele, M.K., Knöferl, M.W., Schwacha, M.G., Ayala, A., Bland, K.I., Cioffi, W.G., Josephson, S.L., Chaudry, I.H. Ann. Surg. (1999) [Pubmed]
  4. Embolization for vertebral metastases of follicular thyroid carcinoma. Smit, J.W., Vielvoye, G.J., Goslings, B.M. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  5. Hepatic transcatheter arterial chemoembolization alternating with systemic protracted continuous infusion 5-fluorouracil for gastrointestinal malignancies metastatic to liver: a phase II trial of the Puget Sound Oncology Consortium (PSOC 1104). Bavisotto, L.M., Patel, N.H., Althaus, S.J., Coldwell, D.M., Nghiem, H.V., Thompson, T., Storer, B., Thomas, C.R. Clin. Cancer Res. (1999) [Pubmed]
  6. Laccase stabilization by covalent binding immobilization on activated polyvinyl alcohol carrier. Yinghui, D., Qiuling, W., Shiyu, F. Lett. Appl. Microbiol. (2002) [Pubmed]
  7. Islet cell tumors metastatic to the liver: effective palliation by sequential hepatic artery embolization. Ajani, J.A., Carrasco, C.H., Charnsangavej, C., Samaan, N.A., Levin, B., Wallace, S. Ann. Intern. Med. (1988) [Pubmed]
  8. Sustained release of epidermal growth factor accelerates wound repair. Buckley, A., Davidson, J.M., Kamerath, C.D., Wolt, T.B., Woodward, S.C. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  9. Modulation of macrophage phenotype by soluble product(s) released from neutrophils. Daley, J.M., Reichner, J.S., Mahoney, E.J., Manfield, L., Henry, W.L., Mastrofrancesco, B., Albina, J.E. J. Immunol. (2005) [Pubmed]
  10. Glucocorticoid dynamics and impaired wound healing in diabetes mellitus. Bitar, M.S. Am. J. Pathol. (1998) [Pubmed]
  11. Activation of mutant forms of DnaA protein of Escherichia coli by DnaK and GrpE proteins occurs prior to DNA replication. Hupp, T.R., Kaguni, J.M. J. Biol. Chem. (1993) [Pubmed]
  12. Travelers' diarrhea in West Africa and Mexico: fecal transport systems and liquid bismuth subsalicylate for self-therapy. Steffen, R., Mathewson, J.J., Ericsson, C.D., DuPont, H.L., Helminger, A., Balm, T.K., Wolff, K., Witassek, F. J. Infect. Dis. (1988) [Pubmed]
  13. L-687,908, a potent hydroxyethylene-containing HIV protease inhibitor. Vacca, J.P., Guare, J.P., deSolms, S.J., Sanders, W.M., Giuliani, E.A., Young, S.D., Darke, P.L., Zugay, J., Sigal, I.S., Schleif, W.A. J. Med. Chem. (1991) [Pubmed]
  14. Intravenous versus superior mesenteric artery vasopressin infusions for the treatment of variceal bleeding. Burgener, F.A., Gutierrez, O.H. Radiology. (1982) [Pubmed]
  15. Thalidomide reduces vascular density in granulation tissue of subcutaneously implanted polyvinyl alcohol sponges in guinea pigs. Or, R., Feferman, R., Shoshan, S. Exp. Hematol. (1998) [Pubmed]
  16. Plasma exchange with selective immunoadsorption of anti-acetylcholine receptor antibodies. Somnier, F.E., Langvad, E. J. Neuroimmunol. (1989) [Pubmed]
  17. Enhancement of recA protein-promoted DNA strand exchange activity by volume-occupying agents. Lavery, P.E., Kowalczykowski, S.C. J. Biol. Chem. (1992) [Pubmed]
  18. The crystal structures at 2.2-A resolution of hydroxyethylene-based inhibitors bound to human immunodeficiency virus type 1 protease show that the inhibitors are present in two distinct orientations. Murthy, K.H., Winborne, E.L., Minnich, M.D., Culp, J.S., Debouck, C. J. Biol. Chem. (1992) [Pubmed]
  19. X-ray analyses of aspartic proteinases. III Three-dimensional structure of endothiapepsin complexed with a transition-state isostere inhibitor of renin at 1.6 A resolution. Veerapandian, B., Cooper, J.B., Sali, A., Blundell, T.L. J. Mol. Biol. (1990) [Pubmed]
  20. Single-cell analysis using capillary electrophoresis: influence of surface support properties on cell injection into the capillary. Krylov, S.N., Dovichi, N.J. Electrophoresis (2000) [Pubmed]
  21. Effects of interleukin-8 on granulation tissue maturation. Moyer, K.E., Saggers, G.C., Allison, G.M., Mackay, D.R., Ehrlich, H.P. J. Cell. Physiol. (2002) [Pubmed]
  22. Suppression of the anti-DNP IgE response with tolerogenic conjugates of DNP with polyvinyl alcohol. II. Induction of hapten-specific suppressor T cells. Lee, W.Y., Sehon, A.H. J. Immunol. (1981) [Pubmed]
  23. Uptake of polyvinyl alcohol by macrophages in the glomerular mesangium of rats. Histologic and functional studies. Sterzel, R.B., Eisenbach, G.M., Seiler, M.W., Hoyer, J.R. Am. J. Pathol. (1983) [Pubmed]
  24. Lymphocyte participation in wound healing. Morphologic assessment using monoclonal antibodies. Fishel, R.S., Barbul, A., Beschorner, W.E., Wasserkrug, H.L., Efron, G. Ann. Surg. (1987) [Pubmed]
  25. Experimental canine hepatic artery embolization with polyvinyl alcohol foam particles. Chuang, V.P., Tsai, C.C., Soo, C.S., Wright, K., Wallace, S., Charnsangavej, C. Radiology. (1982) [Pubmed]
  26. Chitin-based embolic materials in the renal artery of rabbits: pathologic evaluation of an absorbable particulate agent. Kwak, B.K., Shim, H.J., Han, S.M., Park, E.S. Radiology. (2005) [Pubmed]
  27. Origin of the acidity enhancement of formic acid over methanol: resonance versus inductive effects. Holt, J., Karty, J.M. J. Am. Chem. Soc. (2003) [Pubmed]
  28. Development of a biopolymeric keratoprosthetic material. Evaluation in vitro and in vivo. Trinkaus-Randall, V., Capecchi, J., Newton, A., Vadasz, A., Leibowitz, H., Franzblau, C. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  29. Separation of fluorescein isothiocyanate-labeled amines by microchip electrophoresis in uncoated and polyvinyl alcohol-coated glass chips using water and dimethyl sulfoxide as solvents of background electrolyte. Varjo, S.J., Ludwig, M., Belder, D., Riekkola, M.L. Electrophoresis (2004) [Pubmed]
  30. Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design. Turner, R.T., Koelsch, G., Hong, L., Castanheira, P., Ermolieff, J., Ghosh, A.K., Tang, J., Castenheira, P., Ghosh, A. Biochemistry (2001) [Pubmed]
  31. Enhanced angiogenesis characteristic of SPARC-null mice disappears with age. Reed, M.J., Bradshaw, A.D., Shaw, M., Sadoun, E., Han, N., Ferara, N., Funk, S., Puolakkainen, P., Sage, E.H. J. Cell. Physiol. (2005) [Pubmed]
  32. SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges. Puolakkainen, P.A., Bradshaw, A.D., Brekken, R.A., Reed, M.J., Kyriakides, T., Funk, S.E., Gooden, M.D., Vernon, R.B., Wight, T.N., Bornstein, P., Sage, E.H. J. Histochem. Cytochem. (2005) [Pubmed]
  33. Stimulation of the development of bovine embryos by insulin and insulin-like growth factor-I (IGF-I) is mediated through the IGF-I receptor. Matsui, M., Takahashi, Y., Hishinuma, M., Kanagawa, H. Theriogenology (1997) [Pubmed]
  34. Inhibition of BACE, a promising approach to Alzheimer's disease therapy. Roggo, S. Current topics in medicinal chemistry. (2002) [Pubmed]
  35. Supplemental vitamin A prevents the acute radiation-induced defect in wound healing. Levenson, S.M., Gruber, C.A., Rettura, G., Gruber, D.K., Demetriou, A.A., Seifter, E. Ann. Surg. (1984) [Pubmed]
  36. Midterm results of uterine artery embolization for symptomatic adenomyosis: initial experience. Pelage, J.P., Jacob, D., Fazel, A., Namur, J., Laurent, A., Rymer, R., Le Dref, O. Radiology. (2005) [Pubmed]
  37. Control of carcinoid syndrome with hepatic artery embolization. Mitty, H.A., Warner, R.R., Newman, L.H., Train, J.S., Parnes, I.H. Radiology. (1985) [Pubmed]
  38. Outcome of subcutaneous islet transplantation improved by polymer device. Juang, J.H., Bonner-Weir, S., Ogawa, Y., Vacanti, J.P., Weir, G.C. Transplantation (1996) [Pubmed]
  39. Capillary electrophoresis and capillary electrophoresis-electrospray-mass spectroscopy for the analysis of heterocyclic amines. Zhao, Y., Schelfaut, M., Sandra, P., Banks, F. Electrophoresis (1998) [Pubmed]
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