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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Waldenström's macroglobulinemia: prognostic factors and recent therapeutic advances.

Waldenström's macroglobulinemia is a rare B cell malignancy. All prognostic studies have identified the adverse prognostic effect of advanced age and low hemoglobin level for survival, whereas the prognostic value of a high level of monoclonal component remains controversial. Response to treatment is probably a favorable prognostic factor for overall survival. Conventional treatment is based on alkylating agents, and especially chlorambucil. Purine analogues, used initially for salvage treatment, are increasingly employed as front-line therapy. Purine analogues have not been compared with alkylating agents as first-line therapy in randomized trials, and it is unclear whether purine analogues extend survival. An anti-CD20 monoclonal antibody has given a response rate in about 30% of patients. Autologous and allogeneic stem cell transplantation may be considered for patients with refractory or relapsing disease.[1]

References

  1. Waldenström's macroglobulinemia: prognostic factors and recent therapeutic advances. Leblond, V., Tournilhac, O., Morel, P. Clin. Exp. Med. (2004) [Pubmed]
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