A PDZ switch for a cellular stress response.
The accumulation of misfolded porins in the periplasm of bacteria triggers a proteolytic cascade, initiated by activation of DegS, a member of the family of HtrA proteases. Activation of DegS ultimately leads to the expression of genes encoding the periplasmic protein folding machinery. A new study now reveals that binding of exposed C-termini of unassembled porins to the PDZ domain of DegS induces structural rearrangements that activate the catalytic site of the protease domain.[1]References
- A PDZ switch for a cellular stress response. Schlieker, C., Mogk, A., Bukau, B. Cell (2004) [Pubmed]
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