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Murray, J.C. et al.

Murray, Schutte,

Cleft palate: players, pathways, and pursuits.

Cleft lip and palate is a common human birth defect, and its causes are being dissected through studies of human populations and through the use of animal models. Mouse models in particular have made a substantial contribution to our understanding of the gene pathways involved in palate development and the nature of signaling molecules that act in a tissue-specific manner at critical stages of embryogenesis. Related work has provided further support for investigating the role of common environmental triggers as causal covariates.[1]

References

Cleft palate: players, pathways, and pursuits. Murray, J.C., Schutte, B.C. J. Clin. Invest. (2004) [Pubmed]

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