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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

HPLC profiling of Trp-related metabolites in humans.

Screening for metabolic abnormalities of Trp has been introduced using SPE pre-treatment, TLC and/or two HPLC procedures. The excretory pattern in urine (occasionally also plasma and CSF levels) has been followed in a group of 390 children showing various symptoms of a metabolic defect and in 195 patients with skin diseases, namely those associated with photosensitivity, such as porphyria, vitiligo, alopecia, psoriasis, erythematodes, and others. Excretory abnormalities of either indican, kynurenine, 3-hydroxyanthranilic acid or indolylacryloylglycine have been occasionally combined with myopathy, seizures, liver and intestinal symptoms. Several indoles and kynurenine derivatives present changes in the alopecia group and the vitiliginous patients.[1]


  1. HPLC profiling of Trp-related metabolites in humans. Marklová, E., Albahri, Z., Nozicková, M. Adv. Exp. Med. Biol. (2003) [Pubmed]
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