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MeSH Review


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Disease relevance of Alopecia


Psychiatry related information on Alopecia


High impact information on Alopecia


Chemical compound and disease context of Alopecia


Biological context of Alopecia


Anatomical context of Alopecia

  • The incidence of antibodies to individual hair follicle antigens in alopecia areata was up to seven times more frequent than in control sera and their level up to 13 times greater and was statistically significant for all five antigens [26].
  • Increased androgen binding capacity in sebaceous glands in scalp of male-pattern baldness [27].
  • Expression of the L-fucose moiety on infrainfundibular follicular keratinocytes of terminal follicles, its decreased expression on vellus and indeterminate follicles of androgenetic alopecia, and re-expression in drug-induced hair regrowth [28].
  • These data show that many patients with APS I have high-titer autoantibodies directed against the anagen matrix, cuticle, and cortex keratinocytes and a melanocyte nuclear antigen, and also that the hair follicle keratinocyte staining is associated with alopecia, especially alopecia totalis [29].
  • This study is an investigation of the function of peripheral blood monocytes from normal subjects and patients with AA, AU, and alopecia totalis (AT), with respect to the principal macrophage-derived angiogenic factor, tumor necrosis factor alpha (TNF alpha) [30].

Gene context of Alopecia

  • ATIC 347GG was associated with gastrointestinal side effects (OR 3.0, P < 0.01), while TSER*2/*2 (OR 5.4, P < 0.01) and SHMT1 1420CC (OR 3.2, P < 0.01) were associated with alopecia [31].
  • The possible role of TNF-alpha in the pathogenesis of alopecia areata may be called into question if our observation is repeated [32].
  • Recurrence of alopecia areata in a patient receiving etanercept injections [32].
  • Association analysis of IL1A and IL1B variants in alopecia areata [33].
  • This was due mainly to the contribution from mild cases of alopecia areata [OR 1.48 (0.96, 2.29)], suggesting that IL-1 alpha may have a particular role in the pathogenesis of this subgroup [33].

Analytical, diagnostic and therapeutic context of Alopecia


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  2. Endocrinological disorders and celiac disease. Collin, P., Kaukinen, K., Välimäki, M., Salmi, J. Endocr. Rev. (2002) [Pubmed]
  3. Familial Schmidt's syndrome. Anderson, P.B., Fein, S.H., Frey, W.G. JAMA (1980) [Pubmed]
  4. Randomized trial of doxorubicin, bisantrene, and mitoxantrone in advanced breast cancer: a Southwest Oncology Group study. Cowan, J.D., Neidhart, J., McClure, S., Coltman, C.A., Gumbart, C., Martino, S., Hutchins, L.F., Stephens, R.L., Vaughan, C.B., Osborne, C.K. J. Natl. Cancer Inst. (1991) [Pubmed]
  5. Topical cyclosporin in alopecia areata and nickel contact dermatitis. Thompson, A.W., Aldridge, R.D., Sewell, H.F. Lancet (1986) [Pubmed]
  6. Congenital universal alopecia, mental deficiency, and microcephaly in two sibs. Pfeiffer, R.A., Völklein, J. J. Med. Genet. (1982) [Pubmed]
  7. An endocrinopathy characterized by dysfunction of the pituitary-adrenal axis and alopecia universalis: supporting the entity of a triple H syndrome. Ichiki, K., Nakamura, T., Fujita, N., Honda, K., Hiraga, T., Ishibashi, S., Ishikawa, S. Eur. J. Endocrinol. (2002) [Pubmed]
  8. Alopecia areata and affected skin CRH receptor upregulation induced by acute emotional stress. Katsarou-Katsari, A., Singh, L.K., Theoharides, T.C. Dermatology (Basel) (2001) [Pubmed]
  9. Patient treatment preference in advanced breast cancer: a randomized cross-over study of doxorubicin and mitozantrone. Stuart-Harris, R., Simes, R.J., Coates, A.S., Raghavan, D., Devine, R., Tattersall, M.H. European journal of cancer & clinical oncology. (1987) [Pubmed]
  10. The pleiotropic expression of the myotonic dystrophy protein kinase gene illustrates the complex relationships between genetic, biological and clinical covariates of male aging. Brisson, D., Houde, G., St-Pierre, J., Vohl, M.C., Mathieu, J., Gaudet, D. The aging male : the official journal of the International Society for the Study of the Aging Male. (2002) [Pubmed]
  11. Alopecia associated with indinavir therapy. Bouscarat, F., Prevot, M.H., Matheron, S. N. Engl. J. Med. (1999) [Pubmed]
  12. Clinical variation of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) in a series of 68 patients. Ahonen, P., Myllärniemi, S., Sipilä, I., Perheentupa, J. N. Engl. J. Med. (1990) [Pubmed]
  13. Failure of high-dose tocopherol to prevent alopecia induced by doxorubicin. Martin-Jimenez, M., Diaz-Rubio, E., Gonzalez Larriba, J.L., Sangro, B. N. Engl. J. Med. (1986) [Pubmed]
  14. Possible prevention of adriamycin-induced alopecia by tocopherol. Wood, L.A. N. Engl. J. Med. (1985) [Pubmed]
  15. Selective alopecia with mitoxantrone. Arlin, Z.A., Friedland, M.L., Atamer, M.A. N. Engl. J. Med. (1984) [Pubmed]
  16. Male pattern alopecia regrowth following topical fluorouracil therapy. Rietschel, R.L., Madorsky, D.D. JAMA (1977) [Pubmed]
  17. Alopecia associated with ibuprofen. Meyer, H.C. JAMA (1979) [Pubmed]
  18. Cisplatin combined with carboplatin: a new way of intensification of platinum dose in the treatment of advanced ovarian cancer. Belgian Study Group for Ovarian Carcinoma. Piccart, M.J., Nogaret, J.M., Marcelis, L., Longrée, H., Ries, F., Kains, J.P., Gobert, P., Domange, A.M., Sculier, J.P., Gompel, C. J. Natl. Cancer Inst. (1990) [Pubmed]
  19. Minoxidil for male-pattern baldness. Mitchell, A.D., De Villez, R. Lancet (1987) [Pubmed]
  20. Dinitrochlorobenzene in alopecia areata. Breuillard, F., Szapiro, E. Lancet (1978) [Pubmed]
  21. Polymorphism of the androgen receptor gene is associated with male pattern baldness. Ellis, J.A., Stebbing, M., Harrap, S.B. J. Invest. Dermatol. (2001) [Pubmed]
  22. Genetic analysis of male pattern baldness and the 5alpha-reductase genes. Ellis, J.A., Stebbing, M., Harrap, S.B. J. Invest. Dermatol. (1998) [Pubmed]
  23. Chronic active hepatitis associated with vitiligo, nail dystrophy, alopecia and a new variant of LKM antibodies. Sacher, M., Blümel, P., Thaler, H., Manns, M. J. Hepatol. (1990) [Pubmed]
  24. Successful treatment of alopecia areata-like hair loss with the contact sensitizer squaric acid dibutylester (SADBE) in C3H/HeJ mice. Freyschmidt-Paul, P., Sundberg, J.P., Happle, R., McElwee, K.J., Metz, S., Boggess, D., Hoffmann, R. J. Invest. Dermatol. (1999) [Pubmed]
  25. Refined localization of the gene for Clouston syndrome (hidrotic ectodermal dysplasia) in a large French family. Lamartine, J., Laoudj, D., Blanchet-Bardon, C., Kibar, Z., Soularue, P., Ridoux, V., Dubertret, L., Rouleau, G.A., Waksman, G. Br. J. Dermatol. (2000) [Pubmed]
  26. Antibodies to hair follicles in alopecia areata. Tobin, D.J., Orentreich, N., Fenton, D.A., Bystryn, J.C. J. Invest. Dermatol. (1994) [Pubmed]
  27. Increased androgen binding capacity in sebaceous glands in scalp of male-pattern baldness. Sawaya, M.E., Honig, L.S., Hsia, S.L. J. Invest. Dermatol. (1989) [Pubmed]
  28. Expression of the L-fucose moiety on infrainfundibular follicular keratinocytes of terminal follicles, its decreased expression on vellus and indeterminate follicles of androgenetic alopecia, and re-expression in drug-induced hair regrowth. Heng, M.C., Levine, S., Fine, H., Allen, S.G., Heng, M.K. J. Invest. Dermatol. (1992) [Pubmed]
  29. Antibodies against hair follicles are associated with alopecia totalis in autoimmune polyendocrine syndrome type I. Hedstrand, H., Perheentupa, J., Ekwall, O., Gustafsson, J., Michaëlsson, G., Husebye, E., Rorsman, F., Kämpe, O. J. Invest. Dermatol. (1999) [Pubmed]
  30. Angiogenic activity is defective in monocytes from patients with alopecia universalis. Skoutelis, A., Freinkel, R.K., Kaufman, D.S., Leibovich, S.J. J. Invest. Dermatol. (1990) [Pubmed]
  31. Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis. Weisman, M.H., Furst, D.E., Park, G.S., Kremer, J.M., Smith, K.M., Wallace, D.J., Caldwell, J.R., Dervieux, T. Arthritis Rheum. (2006) [Pubmed]
  32. Recurrence of alopecia areata in a patient receiving etanercept injections. Posten, W., Swan, J. Archives of dermatology. (2005) [Pubmed]
  33. Association analysis of IL1A and IL1B variants in alopecia areata. Tazi-Ahnini, R., McDonagh, A.J., Cox, A., Messenger, A.G., Britton, J.E., Ward, S.J., Båvik, C.O., Duff, G.W., Cork, M.J. Heredity (2001) [Pubmed]
  34. Dalteparin-induced alopecia in hemodialysis patients: reversal by regional citrate anticoagulation. Apsner, R., Hörl, W.H., Sunder-Plassmann, G. Blood (2001) [Pubmed]
  35. Interleukin 1 protects against 1-beta-D-arabinofuranosylcytosine-induced alopecia in the newborn rat animal model. Hussein, A.M. Cancer Res. (1991) [Pubmed]
  36. Topical minoxidil. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in alopecia areata and alopecia androgenetica. Clissold, S.P., Heel, R.C. Drugs (1987) [Pubmed]
  37. Tacrolimus-induced alopecia in female kidney-pancreas transplant recipients. Tricot, L., Lebbé, C., Pillebout, E., Martinez, F., Legendre, C., Thervet, E. Transplantation (2005) [Pubmed]
  38. Cyclophosphamide toxicity. Characterising and avoiding the problem. Fraiser, L.H., Kanekal, S., Kehrer, J.P. Drugs (1991) [Pubmed]
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