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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Oral immunization with an rfaH mutant elicits protection against salmonellosis in mice.

Loss of the transcriptional antiterminator RfaH results in virulence attenuation (>10(4)-fold increase in 50% lethal dose) of the archetypal Salmonella enterica serovar Typhimurium strain SL1344 by both orogastric and intraperitoneal routes of infection in BALB/c mice. Oral immunization with the mutant efficiently protects mice against a subsequent oral infection with the wild-type strain. Interestingly, in vitro immunoreactivity is not confined to strain SL1344; rather, it is directed also towards other serovars of S. enterica and even Salmonella bongori strains.[1]

References

  1. Oral immunization with an rfaH mutant elicits protection against salmonellosis in mice. Nagy, G., Dobrindt, U., Hacker, J., Emödy, L. Infect. Immun. (2004) [Pubmed]
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