Disease relevance of Salmonella Infections

• Salmonellosis complicating ulcerative colitis. Treatment with trimethoprim-sulfamethoxazole [1].
• These results suggest that the Ity locus may be closely related to the expression of hsp by macrophages after infection with Salmonella, which in turn stimulate the gamma delta T cells in the host during an early phase of salmonellosis [2].
• Patients with cholera, shigellosis, and infections due to Vibrio parahaemolyticus showed both clinical and bacteriologic responses to fleroxacin treatment, whereas patients with salmonellosis showed only bacteriologic responses [3].
• Administration of zidovudine or cotrimoxazole as prophylaxis against Pneumocystis carinii pneumonia may prevent the development of salmonellosis: significantly fewer patients with this infection were taking these drugs than patients with Campylobacter [4].
• Cephalosporin-resistant Escherichia coli among summer camp attendees with salmonellosis [5].

High impact information on Salmonella Infections

• Salmonellosis: host immune responses and bacterial virulence determinants [6].
• Sixteen percent of the isolates were resistant to ceftriaxone, the drug of choice for treating salmonellosis in children [7].
• This nationwide outbreak of salmonellosis was most likely the result of contamination of pasteurized ice cream premix during transport in tanker trailers that had previously carried nonpasteurized liquid eggs containing S. enteritidis [8].
• Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. I. Effects on microbial killing by activated peritoneal macrophages in vitro [9].
• Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo [10].

Chemical compound and disease context of Salmonella Infections

• OBJECTIVE: To determine the efficacy of ciprofloxacin therapy in eradicating convalescent fecal excretion of salmonellae after acute salmonellosis [11].
• Treatment of mice with celecoxib during salmonellosis resulted in increased viable bacteria in the mesenteric lymph nodes by day 3 postinfection [12].
• Iron chelation via deferoxamine exacerbates experimental salmonellosis via inhibition of the nicotinamide adenine dinucleotide phosphate oxidase-dependent respiratory burst [13].
• Cephalosporin therapy for salmonellosis. Questions of efficacy and cross resistance with ampicillin [14].
• One of the most likely candidates for the lethal toxin in salmonellosis is endotoxin, specifically the lipid A domain of the lipopolysaccharide (LPS) molecule [15].

Biological context of Salmonella Infections

• This evidence shows that L-Sel is important for development of mucosal immunity, and absence of L-Sel is protective against salmonellosis [16].
• Two plasmids which express either nearly intact or truncated filamentous hemagglutinin (FHA) from Bordetella pertussis and which are marked with a tetracycline resistance (Tcr) gene were transformed into Salmonella dublin SL1438, an aroA deletion mutant intended for use as an attenuated oral vaccine against salmonellosis [17].
• On the basis of this conserved synteny, this resistance gene seems unlikely to correspond to the previously identified salmonellosis resistance genes Lps (located on mouse Chr 4) or Nos(2) (located on mouse Chr 11) [18].
• The toxin had no appreciable effect on the course of salmonellosis or on resistance to infection initiated by inhalation of L monocytogenes or M bovis aerosols [19].
• Because salmonellosis often is associated with stress, the effects of norepinephrine on in vitro growth, and in vivo pathogenicity of the swine pathogen Salmonella choleraesuis were investigated [20].

Anatomical context of Salmonella Infections

• Successful resolution of salmonellosis in naive mice depends in large part upon IL-12-induced IFN-gamma production to eliminate this intracellular pathogen of macrophages [21].
• Nontyphoidal salmonellosis is prevalent from April to October in Akita, when the mean atmospheric temperature exceeds 10 degrees C. On physical examination, 3 patients had rebound tenderness and muscle guarding on their abdominal wall; 1 of these patients underwent surgery for associated acute appendicitis [22].

Gene context of Salmonella Infections

• Serum IFN-gamma, IL-12 and IL-18 levels were increased significantly in patients with salmonellosis [23].
• To elucidate the involvement of endogenous IL-10 in the early stage of murine salmonellosis, we examined the effect of anti-IL-10 monoclonal antibody (mAb) administration on the host defence mechanism against Salmonella choleraesuis infection [24].
• Protective effect of recombinant tumor necrosis factor-alpha in murine salmonellosis [25].
• Differential regulation of enteric and systemic salmonellosis by slyA [26].
• Oral immunization with an rfaH mutant elicits protection against salmonellosis in mice [27].

Analytical, diagnostic and therapeutic context of Salmonella Infections

• Adoptive transfer of murine host protection to salmonellosis with T-cell growth factor-dependent, Salmonella-specific T-cell lines [28].
• Therefore, the effect of immunosuppression with cyclosporin A and FK-506 on the course of murine salmonellosis was tested [29].
• In a controlled, randomized, double-blind study, 100 patients (66 women, 34 men; age 18-69 years) with acute salmonellosis were treated with norfloxacin (400 mg) or placebo tablets twice daily for 10 days to compare the effects on the excretion time of salmonella bacteria [30].
• The results demonstrated that cyclosporine reduced in vitro T-cell responses to T-cell-specific mitogens, suppressed in vivo delayed-type hypersensitivity (tuberculin skin-test reactions), and impaired the development of native resistance to salmonellosis [31].
• The significance of these antiporin IgG subclass antibodies in protection against murine Salmonellosis was studied by passive immunization and by analysing the infected mouse sera [32].

References