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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Synaptic scaffolding molecule interacts with axin.

Synaptic scaffolding molecule (S-SCAM) is a synaptic protein that consists of PDZ domains, a guanylate kinase domain, and WW domains. It interacts with N-methyl-d-aspartate receptor subunits, neuroligin, and beta-catenin. Here, we identified Axin as a novel binding partner of S-SCAM. Axin was co-immunoprecipitated with S-SCAM from rat brain, detected in the post-synaptic density fraction in rat brain subcellular fractionation, and partially co-localized with S-SCAM in neurons. The guanylate kinase domain of S-SCAM directly bound to the GSK3beta- binding region of Axin. S-SCAM formed a complex with beta-catenin and Axin, but competed with GSK3beta for Axin-binding. Thereby, S-SCAM inhibited the Axin- mediated phosphorylation of beta-catenin by GSK3beta.[1]

References

  1. Synaptic scaffolding molecule interacts with axin. Hirabayashi, S., Nishimura, W., Iida, J., Kansaku, A., Kishida, S., Kikuchi, A., Tanaka, N., Hata, Y. J. Neurochem. (2004) [Pubmed]
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