The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Nlgn1  -  neuroligin 1

Rattus norvegicus

Synonyms: Neuroligin I, Neuroligin-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Nlgn1


Biological context of Nlgn1

  • Synaptic cell adhesion and synaptogenesis are thought to involve the interaction of neuroligin, a postsynaptic transmembrane protein, with its presynaptic ligand neurexin [4].
  • Using expression of GFP-tagged versions of neuroligin in cultured hippocampal neurons, we find that neuroligin is targeted to synapses via intracellular sequences distinct from its SAP90/PSD95 binding site [4].
  • We conclude that neurexin 1beta and neuroligin 1 (and, by extension, other beta-neurexins and neuroligins) function as heterophilic cell adhesion molecules in a Ca2+-dependent reaction that is regulated by alternative splicing of beta-neurexins [5].
  • Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry [6].

Anatomical context of Nlgn1


Associations of Nlgn1 with chemical compounds


Physical interactions of Nlgn1


Regulatory relationships of Nlgn1


Other interactions of Nlgn1


Analytical, diagnostic and therapeutic context of Nlgn1


  1. Alternative splicing controls selective trans-synaptic interactions of the neuroligin-neurexin complex. Chih, B., Gollan, L., Scheiffele, P. Neuron (2006) [Pubmed]
  2. A preformed complex of postsynaptic proteins is involved in excitatory synapse development. Gerrow, K., Romorini, S., Nabi, S.M., Colicos, M.A., Sala, C., El-Husseini, A. Neuron (2006) [Pubmed]
  3. Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Song, J.Y., Ichtchenko, K., Südhof, T.C., Brose, N. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Synaptic targeting of neuroligin is independent of neurexin and SAP90/PSD95 binding. Dresbach, T., Neeb, A., Meyer, G., Gundelfinger, E.D., Brose, N. Mol. Cell. Neurosci. (2004) [Pubmed]
  5. Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. Nguyen, T., Südhof, T.C. J. Biol. Chem. (1997) [Pubmed]
  6. Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry. Hoffman, R.C., Jennings, L.L., Tsigelny, I., Comoletti, D., Flynn, R.E., Sudhof, T.C., Taylor, P. Biochemistry (2004) [Pubmed]
  7. Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis. Grifman, M., Galyam, N., Seidman, S., Soreq, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. A cytoplasmic motif targets neuroligin-1 exclusively to dendrites of cultured hippocampal neurons. Rosales, C.R., Osborne, K.D., Zuccarino, G.V., Scheiffele, P., Silverman, M.A. Eur. J. Neurosci. (2005) [Pubmed]
  9. The complexity of PDZ domain-mediated interactions at glutamatergic synapses: a case study on neuroligin. Meyer, G., Varoqueaux, F., Neeb, A., Oschlies, M., Brose, N. Neuropharmacology (2004) [Pubmed]
  10. nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM). Ohtsuka, T., Hata, Y., Ide, N., Yasuda, T., Inoue, E., Inoue, T., Mizoguchi, A., Takai, Y. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  11. Expression of neurexin, neuroligin, and their cytoplasmic binding partners in the pancreatic beta-cells and the involvement of neuroligin in insulin secretion. Suckow, A.T., Comoletti, D., Waldrop, M.A., Mosedale, M., Egodage, S., Taylor, P., Chessler, S.D. Endocrinology (2008) [Pubmed]
  12. Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Araç, D., Boucard, A.A., Ozkan, E., Strop, P., Newell, E., Südhof, T.C., Brunger, A.T. Neuron (2007) [Pubmed]
  13. Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin. Iida, J., Hirabayashi, S., Sato, Y., Hata, Y. Mol. Cell. Neurosci. (2004) [Pubmed]
WikiGenes - Universities