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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Daxx- mediated transcriptional repression of MMP1 gene is reversed by SPOP.

Daxx- mediated transcriptional repression was modulated by a speckled POZ domain protein SPOP which was first identified as an autoantigen from the serum of a scleroderma patient. This is the first report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP reversed the transcriptional repression mediated by Daxx which binds with ETS1 transcription factor to repress ETS1-responsive gene expression. Mutagenesis study suggests that the ability of SPOP to self- associate as well as its ability to bind with Daxx was important for the modulation of Daxx-mediated transcriptional repression.[1]

References

  1. Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP. La, M., Kim, K., Park, J., Won, J., Lee, J.H., Fu, Y.M., Meadows, G.G., Joe, C.O. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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