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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The delta-opioid receptor participates in T-cell development by promoting negative selection.

The delta-opioid receptor-1 (DOR-1) as well as delta-opioid enkephalin peptides are expressed during maturation of T cells, although the functional significance of their expression remains unclear. Based on results which show that the administration of the highly selective delta-opioid agonist D-Pen2, D-Pen5]enkephalin (DPDPE) induces an altered pattern of T-cell differentiation in fetal thymic organ culture (FTOC), we hypothesized that DOR-1 is involved in the negative selection process. Our results show that superantigen-induced clonal deletion is promoted by DPDPE and significantly impaired in DOR-1-deficient mice. These results suggest that delta-opioids may play a homeostatic role in the negative selection process during T-cell development.[1]

References

  1. The delta-opioid receptor participates in T-cell development by promoting negative selection. McCarthy, L.E., Nitsche, J.F., Pintar, J.E., Rogers, T.J. J. Neuroimmunol. (2004) [Pubmed]
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