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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity.

We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 > or = CD10 > or = CD10 x CD3F1 > CD10 x B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 x B6F1 animals and dominant in CD10 x CD3F1 animals.[1]

References

  1. Genetic susceptibility of mice to Candida albicans vaginitis correlates with host estrogen sensitivity. Clemons, K.V., Spearow, J.L., Parmar, R., Espiritu, M., Stevens, D.A. Infect. Immun. (2004) [Pubmed]
 
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