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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice.

Z-ajoene, a major compound containing sulfur in oil-macerated garlic products, exhibited inhibitory effects against scopolamine-induced memory impairment in mice using the Morris water maze test. The effects of Z-ajoene were observed dose-dependently (0.25-25 mg/kg). At the highest dosage, the memory performance of mice was improved compared to normal mice. The acetylcholinesterase (AChE) activity in the brain was reduced by administration of Z-ajoene dose-dependently. However, alliin and diallyl disulfide, organosulfur compounds from garlic, did not improve memory performance nor AChE inhibitory effect. These results suggest that Z-ajoene may act on the cholinergic system and on memory impairment caused by excess activity of AChE.[1]

References

  1. Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice. Yamada, N., Hattori, A., Hayashi, T., Nishikawa, T., Fukuda, H., Fujino, T. Pharmacol. Biochem. Behav. (2004) [Pubmed]
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