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Chemical Compound Review

Allitin     3-prop-2-enyldisulfanylprop- 1-ene

Synonyms: DADS, diAllS2, CHEMBL366603, HSDB 595, ACMC-1CDL1, ...
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Disease relevance of Allyl disulfide


High impact information on Allyl disulfide


Chemical compound and disease context of Allyl disulfide


Biological context of Allyl disulfide


Anatomical context of Allyl disulfide


Associations of Allyl disulfide with other chemical compounds


Gene context of Allyl disulfide


Analytical, diagnostic and therapeutic context of Allyl disulfide


  1. Glutathione-related systems and modulation of extracellular signal-regulated kinases are involved in the resistance of AGS adenocarcinoma gastric cells to diallyl disulfide-induced apoptosis. Filomeni, G., Aquilano, K., Rotilio, G., Ciriolo, M.R. Cancer Res. (2005) [Pubmed]
  2. Diallyl trisulfide-induced apoptosis in human prostate cancer cells involves c-Jun N-terminal kinase and extracellular-signal regulated kinase-mediated phosphorylation of Bcl-2. Xiao, D., Choi, S., Johnson, D.E., Vogel, V.G., Johnson, C.S., Trump, D.L., Lee, Y.J., Singh, S.V. Oncogene (2004) [Pubmed]
  3. Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines. Nakagawa, H., Tsuta, K., Kiuchi, K., Senzaki, H., Tanaka, K., Hioki, K., Tsubura, A. Carcinogenesis (2001) [Pubmed]
  4. Enhancement of diallyl disulfide-induced apoptosis by inhibitors of MAPKs in human HepG2 hepatoma cells. Wen, J., Zhang, Y., Chen, X., Shen, L., Li, G.C., Xu, M. Biochem. Pharmacol. (2004) [Pubmed]
  5. Reactive oxygen species-dependent c-Jun NH2-terminal kinase/c-Jun signaling cascade mediates neuroblastoma cell death induced by diallyl disulfide. Filomeni, G., Aquilano, K., Rotilio, G., Ciriolo, M.R. Cancer Res. (2003) [Pubmed]
  6. Chemoprevention of colon carcinogenesis by organosulfur compounds. Reddy, B.S., Rao, C.V., Rivenson, A., Kelloff, G. Cancer Res. (1993) [Pubmed]
  7. Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. Hosono, T., Fukao, T., Ogihara, J., Ito, Y., Shiba, H., Seki, T., Ariga, T. J. Biol. Chem. (2005) [Pubmed]
  8. Diallyl disulfide (DADS) increases histone acetylation and p21(waf1/cip1) expression in human colon tumor cell lines. Druesne, N., Pagniez, A., Mayeur, C., Thomas, M., Cherbuy, C., Duée, P.H., Martel, P., Chaumontet, C. Carcinogenesis (2004) [Pubmed]
  9. Effects of garlic oil and two of its major organosulfur compounds, diallyl disulfide and diallyl trisulfide, on intestinal damage in rats injected with endotoxin. Chiang, Y.H., Jen, L.N., Su, H.Y., Lii, C.K., Sheen, L.Y., Liu, C.T. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  10. Increased acetylation of histones induced by diallyl disulfide and structurally related molecules. Lea, M.A., Randolph, V.M., Patel, M. Int. J. Oncol. (1999) [Pubmed]
  11. Diallyl disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats. Pedraza-Chaverrí, J., González-Orozco, A.E., Maldonado, P.D., Barrera, D., Medina-Campos, O.N., Hernández-Pando, R. Eur. J. Pharmacol. (2003) [Pubmed]
  12. Allergic contact dermatitis to plants in a Spanish dermatology department: a 7-year review. Cabanillas, M., Fernández-Redondo, V., Toribio, J. Contact Derm. (2006) [Pubmed]
  13. Effects of diallyl disulfide and other donors of sulfane sulfur on the proliferation of human hepatoma cell line (HepG2). Iciek, M.B., Rokita, H.B., Wlodek, L.B. Neoplasma (2001) [Pubmed]
  14. Effects of the garlic compound diallyl disulfide on the metabolism, adherence and cell cycle of HT-29 colon carcinoma cells: evidence of sensitive and resistant sub-populations. Robert, V., Mouillé, B., Mayeur, C., Michaud, M., Blachier, F. Carcinogenesis (2001) [Pubmed]
  15. Diallyl disulfide (DADS) enhances gap-junctional intercellular communication by both direct and indirect mechanisms in rat liver cells. Huard, C., Druesne, N., Guyonnet, D., Thomas, M., Pagniez, A., Le Bon, A.M., Martel, P., Chaumontet, C. Carcinogenesis (2004) [Pubmed]
  16. Diallyl disulfide inhibits p34(cdc2) kinase activity through changes in complex formation and phosphorylation. Knowles, L.M., Milner, J.A. Carcinogenesis (2000) [Pubmed]
  17. Lipopolysaccharide inhibition of rat hepatic microsomal epoxide hydrolase and glutathione S-transferase gene expression irrespective of nuclear factor-kappaB activation. Choi, S.H., Kim, S.G. Biochem. Pharmacol. (1998) [Pubmed]
  18. Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells. Kwon, K.B., Yoo, S.J., Ryu, D.G., Yang, J.Y., Rho, H.W., Kim, J.S., Park, J.W., Kim, H.R., Park, B.H. Biochem. Pharmacol. (2002) [Pubmed]
  19. Impact of garlic organosulfides on p21(H-ras) processing. Singh, S.V. J. Nutr. (2001) [Pubmed]
  20. Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells. Bottone, F.G., Baek, S.J., Nixon, J.B., Eling, T.E. J. Nutr. (2002) [Pubmed]
  21. Metabolism of diallyl disulfide by human liver microsomal cytochromes P-450 and flavin-containing monooxygenases. Teyssier, C., Guenot, L., Suschetet, M., Siess, M.H. Drug Metab. Dispos. (1999) [Pubmed]
  22. Antitumor imidazolyl disulfide IV-2 causes irreversible G(2)/M cell cycle arrest without hyperphosphorylation of cyclin-dependent kinase Cdk1. Vogt, A., Tamura, K., Watson, S., Lazo, J.S. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  23. Dietary agents as histone deacetylase inhibitors. Myzak, M.C., Ho, E., Dashwood, R.H. Mol. Carcinog. (2006) [Pubmed]
  24. Relative activities of organosulfur compounds derived from onions and garlic in increasing tissue activities of quinone reductase and glutathione transferase in rat tissues. Munday, R., Munday, C.M. Nutrition and cancer. (2001) [Pubmed]
  25. Low doses of diallyl disulfide, a compound derived from garlic, increase tissue activities of quinone reductase and glutathione transferase in the gastrointestinal tract of the rat. Munday, R., Munday, C.M. Nutrition and cancer. (1999) [Pubmed]
  26. Diallyl disulfide, a chemopreventive agent in garlic, induces multidrug resistance-associated protein 2 expression. Demeule, M., Brossard, M., Turcotte, S., Regina, A., Jodoin, J., Béliveau, R. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  27. Screening of organosulfur compounds as inhibitors of human CYP2A6. Fujita , K., Kamataki, T. Drug Metab. Dispos. (2001) [Pubmed]
  28. Influence of organosulphur compounds from garlic on the secretion of matrix metalloproteinases and their inhibitor TIMP-1 by cultured HUVEC cells. Meyer, K., Ueberham, E., Gebhardt, R. Cell Biol. Toxicol. (2004) [Pubmed]
  29. Diallyl disulfide induces ERK phosphorylation and alters gene expression profiles in human colon tumor cells. Knowles, L.M., Milner, J.A. J. Nutr. (2003) [Pubmed]
  30. Diallyl disulfide suppresses the growth of human colon tumor cell xenografts in athymic nude mice. Sundaram, S.G., Milner, J.A. J. Nutr. (1996) [Pubmed]
  31. Analysis of responses of garlic derivatives in the pulmonary vascular bed of the rat. Kaye, A.D., De Witt, B.J., Anwar, M., Smith, D.E., Feng, C.J., Kadowitz, P.J., Nossaman, B.D. J. Appl. Physiol. (2000) [Pubmed]
  32. Gadolinium chloride inhibition of rat hepatic microsomal epoxide hydrolase and glutathione S-transferase gene expression. Kim, S.G., Choi, S.H. Drug Metab. Dispos. (1997) [Pubmed]
  33. Inhibition of aflatoxin B1- and N-nitrosodiethylamine-induced liver preneoplastic foci in rats fed naturally occurring allyl sulfides. Haber-Mignard, D., Suschetet, M., Bergès, R., Astorg, P., Siess, M.H. Nutrition and cancer. (1996) [Pubmed]
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