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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

IL-4 in tuberculosis: implications for vaccine design.

Current attempts to find a vaccine for tuberculosis (TB) are based on the assumption that it must drive a Th1 response. We review the evidence that progressive disease might not be due to absence of Th1, but rather to the subversive effect of an unusual Th2-like response, involving interleukin-4 ( IL-4) and IL-4delta2. This Th2-like response can impair bactericidal function and lead to toxicity of tumour necrosis factor-alpha ( TNF-alpha) and to pulmonary fibrosis. If this is important, effective vaccines will need to suppress pre-existing Th2-like activity. Such vaccines are feasible and are active therapeutically in mouse TB.[1]


  1. IL-4 in tuberculosis: implications for vaccine design. Rook, G.A., Hernandez-Pando, R., Dheda, K., Teng Seah, G. Trends Immunol. (2004) [Pubmed]
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