Gene Review:
Hand2 - heart and neural crest derivatives...
Mus musculus
Synonyms:
AI225906, AI661148, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, Dhand, Ehand2, ...
Roy,
Wang,
Gupta,
Charboneau,
Loh,
Barke,
Gottlieb,
Pierce,
Sims,
Yamagishi,
Weihe,
Harriss,
Maika,
Kuziel,
King,
Olson,
Nakagawa,
Srivastava,
Cai,
Jabs,
Kato,
Tada-Oikawa,
Takahashi,
Saito,
Wang,
Nishio,
Hakamada-Taguchi,
Kawanishi,
Kuribayashi,
Abe,
Tamamura,
Yamagishi,
Maeda,
Kato,
Tabata,
Srivastava,
Wakisaka,
Kurisu,
Nakanishi,
Yoshimoto,
Tsutsui,
Okamura,
Firulli,
Krawchuk,
Centonze,
Vargesson,
Virshup,
Conway,
Cserjesi,
Laufer,
Firulli,
Srivastava,
Thomas,
Lin,
Kirby,
Brown,
Olson,
Rossi,
Zlotnik,
Deboy,
Xin,
Byram,
Serpe,
Sanders,
Jones,
- Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Firulli, B.A., Krawchuk, D., Centonze, V.E., Vargesson, N., Virshup, D.M., Conway, S.J., Cserjesi, P., Laufer, E., Firulli, A.B. Nat. Genet. (2005)
- Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. Singh, R.R., Hahn, B.H., Sercarz, E.E. J. Exp. Med. (1996)
- Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. Finkelman, F.D., Madden, K.B., Cheever, A.W., Katona, I.M., Morris, S.C., Gately, M.K., Hubbard, B.R., Gause, W.C., Urban, J.F. J. Exp. Med. (1994)
- Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Yanagisawa, H., Clouthier, D.E., Richardson, J.A., Charité, J., Olson, E.N. Development (2003)
- Improved Outcomes in NOD Mice Treated with a Novel Th2 Cytokine-Biasing NKT Cell Activator. Forestier, C., Takaki, T., Molano, A., Im, J.S., Baine, I., Jerud, E.S., Illarionov, P., Ndonye, R., Howell, A.R., Santamaria, P., Besra, G.S., Dilorenzo, T.P., Porcelli, S.A. J. Immunol. (2007)
- Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. Roy, S., Wang, J., Gupta, S., Charboneau, R., Loh, H.H., Barke, R.A. J. Neuroimmunol. (2004)
- Anti-tumour activity of idiotype-specific, MHC-restricted Th1 and Th2 clones in vitro and in vivo. Lauritzsen, G.F., Weiss, S., Bogen, B. Scand. J. Immunol. (1993)
- Interleukin-18 regulates both Th1 and Th2 responses. Nakanishi, K., Yoshimoto, T., Tsutsui, H., Okamura, H. Annu. Rev. Immunol. (2001)
- The design of vaccines against Helicobacter pylori and their development. Del Giudice, G., Covacci, A., Telford, J.L., Montecucco, C., Rappuoli, R. Annu. Rev. Immunol. (2001)
- Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Weiner, H.L., Friedman, A., Miller, A., Khoury, S.J., al-Sabbagh, A., Santos, L., Sayegh, M., Nussenblatt, R.B., Trentham, D.E., Hafler, D.A. Annu. Rev. Immunol. (1994)
- Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Amsen, D., Blander, J.M., Lee, G.R., Tanigaki, K., Honjo, T., Flavell, R.A. Cell (2004)
- Dietary arginine enhances adhesion molecule and T helper 2 cytokine expression in mice with gut-derived sepsis. Yeh, C.L., Hsu, C.S., Chiu, W.C., Hou, Y.C., Yeh, S.L. Shock (2006)
- Dysregulation of the Th1/Th2 cytokine profile is associated with immunosuppression induced by hypothalamic-pituitary-adrenal axis activation in mice. Viveros-Paredes, J.M., Puebla-Pérez, A.M., Gutiérrez-Coronado, O., Sandoval-Ramírez, L., Villaseñor-García, M.M. Int. Immunopharmacol. (2006)
- Overexpression of CIITA in T Cells Aggravates Th2-Mediated Colitis in Mice. Kim, T.W., Park, H.J., Choi, E.Y., Jung, K.C. J. Korean Med. Sci. (2006)
- The biology of chemokines and their receptors. Rossi, D., Zlotnik, A. Annu. Rev. Immunol. (2000)
- The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002)
- Morphogenesis of the right ventricle requires myocardial expression of Gata4. Zeisberg, E.M., Ma, Q., Juraszek, A.L., Moses, K., Schwartz, R.J., Izumo, S., Pu, W.T. J. Clin. Invest. (2005)
- Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Ruest, L.B., Xiang, X., Lim, K.C., Levi, G., Clouthier, D.E. Development (2004)
- Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development. Togi, K., Yoshida, Y., Matsumae, H., Nakashima, Y., Kita, T., Tanaka, M. Biochem. Biophys. Res. Commun. (2006)
- Tooth-type specific expression of dHAND/Hand2: possible involvement in murine lower incisor morphogenesis. Abe, M., Tamamura, Y., Yamagishi, H., Maeda, T., Kato, J., Tabata, M.J., Srivastava, D., Wakisaka, S., Kurisu, K. Cell Tissue Res. (2002)
- Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Srivastava, D., Thomas, T., Lin, Q., Kirby, M.L., Brown, D., Olson, E.N. Nat. Genet. (1997)
- Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Firulli, A.B., McFadden, D.G., Lin, Q., Srivastava, D., Olson, E.N. Nat. Genet. (1998)
- The basic helix-loop-helix transcription factor, dHAND, is required for vascular development. Yamagishi, H., Olson, E.N., Srivastava, D. J. Clin. Invest. (2000)
- Extra-embryonic vasculature development is regulated by the transcription factor HAND1. Morikawa, Y., Cserjesi, P. Development (2004)
- Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation. Kato, T., Tada-Oikawa, S., Takahashi, K., Saito, K., Wang, L., Nishio, A., Hakamada-Taguchi, R., Kawanishi, S., Kuribayashi, K. Eur. J. Immunol. (2006)
- The progesterone derivative dydrogesterone down-regulates neurokinin 1 receptor expression on lymphocytes, induces a Th2 skew and exerts hypoalgesic effects in mice. Orsal, A.S., Blois, S., Labuz, D., Peters, E.M., Schaefer, M., Arck, P.C. J. Mol. Med. (2006)
- How the MHC selects Th1/Th2 immunity. Murray, J.S. Immunol. Today (1998)
- Differential expression of alpha3 fucosyltransferases in Th1 and Th2 cells correlates with their ability to bind P-selectin. van Wely, C.A., Blanchard, A.D., Britten, C.J. Biochem. Biophys. Res. Commun. (1998)
- The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Charité, J., McFadden, D.G., Olson, E.N. Development (2000)
- Murine interleukin 4 transgenic heart allograft survival prolonged with down-regulation of the Th1 cytokine mRNA in grafts. Takeuchi, T., Ueki, T., Sunaga, S., Ikuta, K., Sasaki, Y., Li, B., Moriyama, N., Miyazaki, J., Kawabe, K. Transplantation (1997)
- Suppression of Th1 and Th2 Immune Responses in Mice by Sinomenine, an Alkaloid Extracted from the Chinese Medicinal Plant Sinomenium acutum. Feng, H., Yamaki, K., Takano, H., Inoue, K., Yanagisawa, R., Yoshino, S. Planta Med. (2006)
- Akt-dependent phosphorylation negatively regulates the transcriptional activity of dHAND by inhibiting the DNA binding activity. Murakami, M., Kataoka, K., Fukuhara, S., Nakagawa, O., Kurihara, H. Eur. J. Biochem. (2004)
- The basic helix-loop-helix factor Hand 2 regulates autonomic nervous system development. Morikawa, Y., Dai, Y.S., Hao, J., Bonin, C., Hwang, S., Cserjesi, P. Dev. Dyn. (2005)
- Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Gottlieb, P.D., Pierce, S.A., Sims, R.J., Yamagishi, H., Weihe, E.K., Harriss, J.V., Maika, S.D., Kuziel, W.A., King, H.L., Olson, E.N., Nakagawa, O., Srivastava, D. Nat. Genet. (2002)
- Mutual genetic antagonism involving GLI3 and dHAND prepatterns the vertebrate limb bud mesenchyme prior to SHH signaling. te Welscher, P., Fernandez-Teran, M., Ros, M.A., Zeller, R. Genes Dev. (2002)
- A twisted hand: bHLH protein phosphorylation and dimerization regulate limb development. Cai, J., Jabs, E.W. Bioessays (2005)
- Suppression of Skin Lesions by Transdermal Application of CpG-Oligodeoxynucleotides in NC/Nga Mice, a Model of Human Atopic Dermatitis. Inoue, J., Aramaki, Y. J. Immunol. (2007)
- The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. Firulli, B.A., Hadzic, D.B., McDaid, J.R., Firulli, A.B. J. Biol. Chem. (2000)
- Immune-mediated neuroprotection of axotomized mouse facial motoneurons is dependent on the IL-4/STAT6 signaling pathway in CD4(+) T cells. Deboy, C.A., Xin, J., Byram, S.C., Serpe, C.J., Sanders, V.M., Jones, K.J. Exp. Neurol. (2006)