Gene Review:
Hand1 - heart and neural crest derivatives...
Mus musculus
Synonyms:
Ehand, Ehand1, Extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1, Heart-and neural crest derivatives-expressed protein 1, Helix-loop-helix transcription factor expressed in extraembryonic mesoderm and trophoblast, ...
Kremer,
Hines,
Milton,
Wheeler,
Henke,
Pearce,
Moaveni,
Moore,
Lynch,
Longo,
Varma,
Dewyer,
Deatrick,
Upchurch,
Wakefield,
Hogaboam,
Kunkel,
Teshima,
Okunuki,
Sato,
Akiyama,
Maitani,
Sawada,
Kraut,
Snider,
Chen,
Tapscott,
Groudine,
Kato,
Tada-Oikawa,
Takahashi,
Saito,
Wang,
Nishio,
Hakamada-Taguchi,
Kawanishi,
Kuribayashi,
Nakanishi,
Yoshimoto,
Tsutsui,
Okamura,
Gately,
Renzetti,
Magram,
Stern,
Adorini,
Gubler,
Presky,
Srivastava,
Thomas,
Lin,
Kirby,
Brown,
Olson,
Nouri-Shirazi,
Tinajero,
Guinet,
Thorbecke,
Umetsu,
deKruyff,
Hansen,
Chen,
Hochwald,
Rossi,
Zlotnik,
Xu,
Manivannan,
Jiang,
Liversidge,
Sharp,
Forrester,
Crane,
- Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. Singh, R.R., Hahn, B.H., Sercarz, E.E. J. Exp. Med. (1996)
- Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites. Finkelman, F.D., Madden, K.B., Cheever, A.W., Katona, I.M., Morris, S.C., Gately, M.K., Hubbard, B.R., Gause, W.C., Urban, J.F. J. Exp. Med. (1994)
- ERK1-/- Mice Exhibit Th1 Cell Polarization and Increased Susceptibility to Experimental Autoimmune Encephalomyelitis. Agrawal, A., Dillon, S., Denning, T.L., Pulendran, B. J. Immunol. (2006)
- Th1 and Type 1 Cytotoxic T Cells Dominate Responses in T-bet Overexpression Transgenic Mice That Develop Contact Dermatitis. Ishizaki, K., Yamada, A., Yoh, K., Nakano, T., Shimohata, H., Maeda, A., Fujioka, Y., Morito, N., Kawachi, Y., Shibuya, K., Otsuka, F., Shibuya, A., Takahashi, S. J. Immunol. (2007)
- Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+-ATPase-Reactive TCR Transgenic Mouse. Katakai, T., Nomura, T., Gonda, H., Sugai, M., Agata, Y., Nishio, A., Masuda, T., Sakaguchi, S., Shimizu, A. J. Immunol. (2006)
- Alcohol consumption alters antigen-specific Th1 responses: mechanisms of deficit and repair. Waltenbaugh, C., Vasquez, K., Peterson, J.D. Alcohol. Clin. Exp. Res. (1998)
- Anti-tumour activity of idiotype-specific, MHC-restricted Th1 and Th2 clones in vitro and in vivo. Lauritzsen, G.F., Weiss, S., Bogen, B. Scand. J. Immunol. (1993)
- Interleukin-18 regulates both Th1 and Th2 responses. Nakanishi, K., Yoshimoto, T., Tsutsui, H., Okamura, H. Annu. Rev. Immunol. (2001)
- The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Gately, M.K., Renzetti, L.M., Magram, J., Stern, A.S., Adorini, L., Gubler, U., Presky, D.H. Annu. Rev. Immunol. (1998)
- Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Trinchieri, G. Annu. Rev. Immunol. (1995)
- Engineered recombinant ovomucoid third domain can desensitize Balb/c mice of egg allergy. Rupa, P., Mine, Y. Allergy (2006)
- Dietary arginine enhances adhesion molecule and T helper 2 cytokine expression in mice with gut-derived sepsis. Yeh, C.L., Hsu, C.S., Chiu, W.C., Hou, Y.C., Yeh, S.L. Shock (2006)
- Comparison of phage pVIII and KLH as vector in inducing the production of cytokines in C57BL/6J mice. Su, Q.P., Wen, D.Z., Yang, Q., Zhang, Y.H., Liu, C., Wang, L. Vaccine (2007)
- The biology of chemokines and their receptors. Rossi, D., Zlotnik, A. Annu. Rev. Immunol. (2000)
- The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002)
- The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Riley, P., Anson-Cartwright, L., Cross, J.C. Nat. Genet. (1998)
- Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Firulli, A.B., McFadden, D.G., Lin, Q., Srivastava, D., Olson, E.N. Nat. Genet. (1998)
- Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2. Hill, A.A., Riley, P.R. Mol. Cell. Biol. (2004)
- Requirement of the mouse I-mfa gene for placental development and skeletal patterning. Kraut, N., Snider, L., Chen, C.M., Tapscott, S.J., Groudine, M. EMBO J. (1998)
- Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart. Togi, K., Kawamoto, T., Yamauchi, R., Yoshida, Y., Kita, T., Tanaka, M. Mol. Cell. Biol. (2004)
- Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation. Kato, T., Tada-Oikawa, S., Takahashi, K., Saito, K., Wang, L., Nishio, A., Hakamada-Taguchi, R., Kawanishi, S., Kuribayashi, K. Eur. J. Immunol. (2006)
- The progesterone derivative dydrogesterone down-regulates neurokinin 1 receptor expression on lymphocytes, induces a Th2 skew and exerts hypoalgesic effects in mice. Orsal, A.S., Blois, S., Labuz, D., Peters, E.M., Schaefer, M., Arck, P.C. J. Mol. Med. (2006)
- Nicotine alters the biological activities of developing mouse bone marrow-derived dendritic cells (DCs). Nouri-Shirazi, M., Tinajero, R., Guinet, E. Immunol. Lett. (2007)
- Histamine Regulates Placental Cytokine Expression - In vivo Study on HDC Knockout Mice. Pap, E., Falus, A., Mih??lyi, D., Borck, H., Diel, F., P??llinger, E. Placenta (2007)
- Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Powrie, F., Menon, S., Coffman, R.L. Eur. J. Immunol. (1993)
- Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta. Yamada, K., Kanda, H., Tanaka, S., Takamatsu, N., Shiba, T., Ito, M. Differentiation (2006)
- How the MHC selects Th1/Th2 immunity. Murray, J.S. Immunol. Today (1998)
- Regulation of cytokine gene expression in T helper cell subsets. Lederer, J.A., Liou, J.S., Todd, M.D., Glimcher, L.H., Lichtman, A.H. J. Immunol. (1994)
- Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. Pfeiffer, C., Stein, J., Southwood, S., Ketelaar, H., Sette, A., Bottomly, K. J. Exp. Med. (1995)
- A multidrug-resistance protein (MRP)-like transmembrane pump is highly expressed by resting murine T helper (Th) 2, but not Th1 cells, and is induced to equal expression levels in Th1 and Th2 cells after antigenic stimulation in vivo. Lohoff, M., Prechtl, S., Sommer, F., Roellinghoff, M., Schmitt, E., Gradehandt, G., Rohwer, P., Stride, B.D., Cole, S.P., Deeley, R.G. J. Clin. Invest. (1998)
- Suppression of Th1 and Th2 Immune Responses in Mice by Sinomenine, an Alkaloid Extracted from the Chinese Medicinal Plant Sinomenium acutum. Feng, H., Yamaki, K., Takano, H., Inoue, K., Yanagisawa, R., Yoshino, S. Planta Med. (2006)
- A standardized root extract of Withania somnifera and its major constituent withanolide-A elicit humoral and cell-mediated immune responses by up regulation of Th1-dominant polarization in BALB/c mice. Malik, F., Singh, J., Khajuria, A., Suri, K.A., Satti, N.K., Singh, S., Kaul, M.K., Kumar, A., Bhatia, A., Qazi, G.N. Life Sci. (2007)
- Effect of Oral Administration of CpG ODN-OVA on WBB6F1-W/Wv Mice. Teshima, R., Okunuki, H., Sato, Y., Akiyama, H., Maitani, T., Sawada, J. Allergology international : official journal of the Japanese Society of Allergology. (2006)
- Recruitment of IFN-gamma-producing (Th1-like) cells into the inflamed retina in vivo is preferentially regulated by P-selectin glycoprotein ligand 1:P/E-selectin interactions. Xu, H., Manivannan, A., Jiang, H.R., Liversidge, J., Sharp, P.F., Forrester, J.V., Crane, I.J. J. Immunol. (2004)
- Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Srivastava, D., Thomas, T., Lin, Q., Kirby, M.L., Brown, D., Olson, E.N. Nat. Genet. (1997)
- Favored T helper 1 response in a mouse model of hepatosteatosis is associated with enhanced T cell-mediated hepatitis. Kremer, M., Hines, I.N., Milton, R.J., Wheeler, M.D. Hepatology (2006)
- Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. Henke, P.K., Pearce, C.G., Moaveni, D.M., Moore, A.J., Lynch, E.M., Longo, C., Varma, M., Dewyer, N.A., Deatrick, K.B., Upchurch, G.R., Wakefield, T.W., Hogaboam, C., Kunkel, S.L. J. Immunol. (2006)
- When engineered to produce latent TGF-beta1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes. Thorbecke, G.J., Umetsu, D.T., deKruyff, R.H., Hansen, G., Chen, L.Z., Hochwald, G.M. Cytokine Growth Factor Rev. (2000)
- Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Hollenberg, S.M., Sternglanz, R., Cheng, P.F., Weintraub, H. Mol. Cell. Biol. (1995)
- Vaccination of mice against intestinal Trichinella spiralis infections by oral administration of antigens microencapsulated in methacrilic acid copolymers. Dea-Ayuela, M.A., Rama-Iñiguez, S., Bolas-Fernández, F. Vaccine (2006)
- Effects of Tributyltin on the Development of Atopic Dermatitis-Like Eruptions in DS-Nh Mice. Iwamura, C., Aihara, M., Nakazawa, M., Takahashi, K., Yoshioka, N., Matsukura, S., Hirasawa, T., Minami, M., Ikezawa, Z. Int. Arch. Allergy Immunol. (2006)
- Effect of sperm DNA vaccine on fertility of female mice. Naz, R.K. Mol. Reprod. Dev. (2006)