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Bravo-Herrera, M.D. et al.

Tissue factor expression is decreased in monocytes obtained from blood during Mediterranean or high carbohydrate diets.

BACKGROUND: Mediterranean and high carbohydrate diets play a dominant role in the prevention of atherosclerosis as a result of their lipid lowering effect. However, diets can also have a protective effect in other ways, such as modulating tissue factor expression in circulating monocytes. METHODS AND RESULTS: Forty-one subjects participated in this randomised crossover study consisting of three dietary periods: a saturated fat enriched diet (SFA), a low fat and high carbohydrate diet (CHO), and a Mediterranean diet. Plasma levels of total cholesterol, triglycerides, low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) were determined at the end of each dietary period, as was the expression of tissue factor ( TF) in circulating monocytes isolated from blood samples. Total cholesterol, LDL-C, HDL-C and TF expression were lower after the Mediterranean and high carbohydrate diets than after the SFA diet, and there was a positive correlation between LDL-C levels and monocyte TF expression. CONCLUSIONS: High carbohydrate and Mediterranean diets reduce the expression of TF in circulating monocytes.[1]

References

Tissue factor expression is decreased in monocytes obtained from blood during Mediterranean or high carbohydrate diets. Bravo-Herrera, M.D., López-Miranda, J., Marín, C., Gómez, P., Gómez, M.J., Moreno, J.A., Pérez-Martínez, P., Blanco, A., Jiménez-Gómez, Y., Pérez-Jiménez, F. Nutrition, metabolism, and cardiovascular diseases : NMCD. (2004) [Pubmed]

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