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MeSH Review

Diet, Mediterranean

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Disease relevance of Diet, Mediterranean


High impact information on Diet, Mediterranean


Biological context of Diet, Mediterranean


Anatomical context of Diet, Mediterranean


Associations of Diet, Mediterranean with chemical compounds

  • INTERVENTION: A cholesterol-lowering Mediterranean diet and a diet of similar energy and fat content in which walnuts replaced approximately 35% of the energy obtained from monounsaturated fat [1].
  • It is likely that certain nutriments characteristic of the Mediterranean diet (omega-3 fatty acids, oleic acid antioxidant vitamins) have specific cardioprotective effects [17].
  • Although the mechanisms are not fully understood, carotenoids, folic acid, and fiber, all abundant in the Mediterranean diet, appear to play important roles in prevention of these diseases [18].
  • We found that women from Granada (Spain), a region with a typically Mediterranean diet, had significantly higher levels of 8-oxodGuo compared with Malmö (Sweden), a region with a Northern European dietary intake pattern (2.30 +/- 0.78 versus 1.59 +/- 1.01 8-oxodGuo/10(-6) deoxyguanosine) [19].
  • Catechin in the Mediterranean diet: vegetable, fruit or wine [20]?

Gene context of Diet, Mediterranean


Analytical, diagnostic and therapeutic context of Diet, Mediterranean


  1. Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial. Zambón, D., Sabaté, J., Muñoz, S., Campero, B., Casals, E., Merlos, M., Laguna, J.C., Ros, E. Ann. Intern. Med. (2000) [Pubmed]
  2. The Mediet Project. Castagnetta, L., Granata, O.M., Cusimano, R., Ravazzolo, B., Liquori, M., Polito, L., Miele, M., Di Cristina, A., Hamel, P., Traina, A. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  3. Weight reduction is not a major reason for improvement in rheumatoid arthritis from lacto-vegetarian, vegan or Mediterranean diets. Sköldstam, L., Brudin, L., Hagfors, L., Johansson, G. Nutrition journal [electronic resource]. (2005) [Pubmed]
  4. Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia. Søndergaard, E., Møller, J.E., Egstrup, K. Am. Heart J. (2003) [Pubmed]
  5. Wine ethanol, platelets, and Mediterranean diet. de Lorgeril, M., Salen, P. Lancet (1999) [Pubmed]
  6. Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J.L., Monjaud, I., Guidollet, J., Touboul, P., Delaye, J. Lancet (1994) [Pubmed]
  7. Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Fuentes, F., López-Miranda, J., Sánchez, E., Sánchez, F., Paez, J., Paz-Rojas, E., Marín, C., Gómez, P., Jimenez-Perepérez, J., Ordovás, J.M., Pérez-Jiménez, F. Ann. Intern. Med. (2001) [Pubmed]
  8. Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: The ATTICA Study. Chrysohoou, C., Panagiotakos, D.B., Pitsavos, C., Das, U.N., Stefanadis, C. J. Am. Coll. Cardiol. (2004) [Pubmed]
  9. A Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy young persons. Pérez-Jiménez, F., López-Miranda, J., Pinillos, M.D., Gómez, P., Paz-Rojas, E., Montilla, P., Marín, C., Velasco, M.J., Blanco-Molina, A., Jiménez Perepérez, J.A., Ordovás, J.M. Diabetologia (2001) [Pubmed]
  10. The role of energy and fat in cancers of the breast and colon-rectum in a southern European population. Franceschi, S., Favero, A. Ann. Oncol. (1999) [Pubmed]
  11. The antioxidant potential of the Mediterranean diet. Ghiselli, A., D'Amicis, A., Giacosa, A. Eur. J. Cancer Prev. (1997) [Pubmed]
  12. The degree of unsaturation of dietary fatty acids and the development of atherosclerosis (review). Moreno, J.J., Mitjavila, M.T. J. Nutr. Biochem. (2003) [Pubmed]
  13. Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans. Leighton, F., Cuevas, A., Guasch, V., Pérez, D.D., Strobel, P., San Martín, A., Urzua, U., Díez, M.S., Foncea, R., Castillo, O., Mizón, C., Espinoza, M.A., Urquiaga, I., Rozowski, J., Maiz, A., Germain, A. Drugs under experimental and clinical research. (1999) [Pubmed]
  14. Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity. Ryan, M., McInerney, D., Owens, D., Collins, P., Johnson, A., Tomkin, G.H. QJM : monthly journal of the Association of Physicians. (2000) [Pubmed]
  15. Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation. Dell'agli, M., Fagnani, R., Mitro, N., Scurati, S., Masciadri, M., Mussoni, L., Galli, G.V., Bosisio, E., Crestani, M., De Fabiani, E., Tremoli, E., Caruso, D. J. Agric. Food Chem. (2006) [Pubmed]
  16. Tissue factor expression is decreased in monocytes obtained from blood during Mediterranean or high carbohydrate diets. Bravo-Herrera, M.D., López-Miranda, J., Marín, C., Gómez, P., Gómez, M.J., Moreno, J.A., Pérez-Martínez, P., Blanco, A., Jiménez-Gómez, Y., Pérez-Jiménez, F. Nutrition, metabolism, and cardiovascular diseases : NMCD. (2004) [Pubmed]
  17. Effect of a mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease. Insights into the cardioprotective effect of certain nutriments. De Lorgeril, M., Salen, P., Martin, J.L., Mamelle, N., Monjaud, I., Touboul, P., Delaye, J. J. Am. Coll. Cardiol. (1996) [Pubmed]
  18. Health implications of Mediterranean diets in light of contemporary knowledge. 1. Plant foods and dairy products. Kushi, L.H., Lenart, E.B., Willett, W.C. Am. J. Clin. Nutr. (1995) [Pubmed]
  19. Oxidative DNA damage in human lymphocytes: correlations with plasma levels of alpha-tocopherol and carotenoids. Bianchini, F., Elmståhl, S., Martinez-Garciá, C., van Kappel, A.L., Douki, T., Cadet, J., Ohshima, H., Riboli, E., Kaaks, R. Carcinogenesis (2000) [Pubmed]
  20. Catechin in the Mediterranean diet: vegetable, fruit or wine? Ruidavets, J., Teissedre, P., Ferrières, J., Carando, S., Bougard, G., Cabanis, J. Atherosclerosis (2000) [Pubmed]
  21. Tracing the Mediterranean diet through principal components and cluster analyses in the Greek population. Costacou, T., Bamia, C., Ferrari, P., Riboli, E., Trichopoulos, D., Trichopoulou, A. European journal of clinical nutrition. (2003) [Pubmed]
  22. Effect of interaction between adherence to a Mediterranean diet and the methylenetetrahydrofolate reductase 677C-->T mutation on homocysteine concentrations in healthy adults: the ATTICA Study. Dedoussis, G.V., Panagiotakos, D.B., Chrysohoou, C., Pitsavos, C., Zampelas, A., Choumerianou, D., Stefanadis, C. Am. J. Clin. Nutr. (2004) [Pubmed]
  23. A Mediterranean dietary style influences TNF-alpha and VCAM-1 coronary blood levels in unstable angina patients. Serrano-Martinez, M., Palacios, M., Martinez-Losa, E., Lezaun, R., Maravi, C., Prado, M., Martínez, J.A., Martinez-Gonzalez, M.A. European journal of nutrition. (2005) [Pubmed]
  24. The postprandial effect of components of the Mediterranean diet on endothelial function. Vogel, R.A., Corretti, M.C., Plotnick, G.D. J. Am. Coll. Cardiol. (2000) [Pubmed]
  25. Adherence to the Mediterranean diet is associated with total antioxidant capacity in healthy adults: the ATTICA study. Pitsavos, C., Panagiotakos, D.B., Tzima, N., Chrysohoou, C., Economou, M., Zampelas, A., Stefanadis, C. Am. J. Clin. Nutr. (2005) [Pubmed]
  26. Randomized trial of the effects of cholesterol-lowering dietary treatment on psychological function. Wardle, J., Rogers, P., Judd, P., Taylor, M.A., Rapoport, L., Green, M., Nicholson Perry, K. Am. J. Med. (2000) [Pubmed]
  27. "The Mediterranean-style diet". Is it ideal for the modern world? De Lorgeril, M. Asia Pacific journal of clinical nutrition. (2004) [Pubmed]
  28. Fibers in the Mediterranean diet. An epidemiological study of the Campania Region. Stefano, G.S., Ruggiero, A.M., Stefano, C.M. Minerva Med. (1997) [Pubmed]
  29. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Ros, E., Núñez, I., Pérez-Heras, A., Serra, M., Gilabert, R., Casals, E., Deulofeu, R. Circulation (2004) [Pubmed]
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