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Jelińska, A. et al.

Jelińska, Dobrowolski, Oszczapowicz,

The influence of pH, temperature and buffers on the degradation kinetics of cefetamet pivoxil hydrochloride in aqueous solutions.

The first-order hydrolysis kinetics of cefetamet pivoxil (CP) were investigated as a function of pH, temperature and buffers. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles for hydrolysis of cefetamet pivoxil were obtained at 333, 343, 353 and 363K. The pH-rate expression was k(pH)=kH+aH+ + kH2OkOH-aOH-, where kH+ and kOH- are the second-order rate constants (mol(-1)ls(-1)) for hydrogen ion activity and for hydroxyl ion activity respectively, and kH2O is the pseudo-first-order rate constant (s(-1)) for spontaneous reaction under the influence of water. The pH-rate profile was characteristically U-shaped. Maximum stability was observed in the pH region from 3 to 5.[1]

References

The influence of pH, temperature and buffers on the degradation kinetics of cefetamet pivoxil hydrochloride in aqueous solutions. Jelińska, A., Dobrowolski, L., Oszczapowicz, I. Journal of pharmaceutical and biomedical analysis. (2004) [Pubmed]

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