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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells.

Serum amyloid A ( SAA) is an acute phase protein that associates with HDL. In order to examine the role of SAA in reverse-cholesterol transport, lipid efflux was tested to SAA from HeLa cells before and after transfection with the ABCA1 transporter. ABCA1 expression increased efflux of cholesterol and phospholipid to SAA by 3-fold and 2-fold, respectively. In contrast to apoA-I, SAA also removed lipid without ABCA1; cholesterol efflux from control cells to SAA was 10-fold higher than for apoA-I. Furthermore, SAA effluxed cholesterol from Tangier disease fibroblasts and from cells after inhibition of ABCA1 by fixation with paraformaldehyde. In summary, SAA can act as a lipid acceptor for ABCA1, but unlike apoA-I, it can also efflux lipid without ABCA1, by most likely a detergent-like extraction process. These results suggest that SAA may play a unique role as an auxiliary lipid acceptor in the removal of lipid from sites of inflammation.[1]

References

  1. Serum amyloid A promotes ABCA1-dependent and ABCA1-independent lipid efflux from cells. Stonik, J.A., Remaley, A.T., Demosky, S.J., Neufeld, E.B., Bocharov, A., Brewer, H.B. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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