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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Cottagnoud, P. et al.

Cottagnoud, Pfister, Acosta, Cottagnoud, Flatz, Kühn, Müller, Stucki,

Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis.

The penetration of daptomycin, a new lipopeptide antibiotic, into inflamed meninges ranged between 4.37 and 7.53% (mean, 5.97%). Daptomycin was very efficacious in the treatment of experimental pneumococcal meningitis, producing a decrease of -1.20 +/- 0.32 Deltalog(10) CFU/ml. h in the bacterial titer of Streptococcus pneumoniae against a penicillin-resistant strain and of -0.97 +/- 0.32 Deltalog(10) CFU/ml. h against a penicillin- and quinolone-resistant strain found in cerebrospinal fluid (CSF). For both strains, daptomycin was significantly superior to the standard regimen of a combination of ceftriaxone with vancomycin, sterilizing 9 of 10 CSF samples after 4 h. In vitro, daptomycin produced highly bactericidal activity in concentrations above the MIC.[1]

References

Daptomycin is highly efficacious against penicillin-resistant and penicillin- and quinolone-resistant pneumococci in experimental meningitis. Cottagnoud, P., Pfister, M., Acosta, F., Cottagnoud, M., Flatz, L., Kühn, F., Müller, H.P., Stucki, A. Antimicrob. Agents Chemother. (2004) [Pubmed]

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