Disease relevance of Meningitis, Pneumococcal

• 68 children with pneumococcal meningitis who survived 24 hours were evaluated, of whom 25 had chloramphenicol-susceptible PRSP meningitis that was treated initially with chloramphenicol [1].
• Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis [2].
• Prevention of hearing loss in experimental pneumococcal meningitis by administration of dexamethasone and ketorolac [3].
• Twenty-nine rabbits with pneumococcal meningitis receiving grepafloxacin at 15 mg/kg of body weight (intravenous administration at 0 h), 30 mg/kg (at 0 h), or 50 mg/kg twice (at 0 and 4 h) were studied [4].
• One child with pneumococcal meningitis and two children with meningococcal meningitis recovered rapidly and without incident during ceftriaxone therapy [5].

Psychiatry related information on Meningitis, Pneumococcal

• In an infant rat model of pneumococcal meningitis the effect of dexamethasone on neuronal injury in the hippocampus and on learning disability after recovery from the disease was examined [6].

High impact information on Meningitis, Pneumococcal

• Administration of methylprednisolone during the early stages of acute pneumococcal meningitis reduced mean peak outflow resistance towards control values (0.59 mm Hg/microliter per min) and no "rebound" effect was apparent 24 h later [7].
• Chloramphenicol in penicillin-resistant pneumococcal meningitis [8].
• We therefore prospectively assessed children with pneumococcal meningitis treated with penicillin plus chloramphenicol over 27 months to compare outcome of penicillin-susceptible S pneumoniae (PSSP) meningitis with that of PRSP meningitis [1].
• Role of Caspase-1 in experimental pneumococcal meningitis: Evidence from pharmacologic Caspase inhibition and Caspase-1-deficient mice [9].
• Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis [10].

Chemical compound and disease context of Meningitis, Pneumococcal

• Pneumococcal meningitis during intravenous ciprofloxacin therapy [11].
• In a mouse model of pneumococcal meningitis, survival and clinical score at 24 hours were significantly improved by triptan treatment [12].
• In summary, 11 adults with pneumococcal meningitis were treated with vancomycin and early adjunctive therapy including dexamethasone [13].
• Experimental study of LY333328 (oritavancin), alone and in combination, in therapy of cephalosporin-resistant pneumococcal meningitis [14].
• In conclusion, in experimental pneumococcal meningitis the activities of new quinolones with improved antipneumococcal activities were comparable to that of ceftriaxone [15].

Biological context of Meningitis, Pneumococcal

• Our study suggests that pial arteriolar vasodilation in the early phase of experimental pneumococcal meningitis is mediated by the neuronal NOS pathway [16].
• Inhibition of glutamine synthetase in rabbit pneumococcal meningitis is associated with neuronal apoptosis in the dentate gyrus [17].
• Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis [18].
• This study investigated whether the 21-aminosteroid U74389F, an inhibitor of lipid peroxidation, attenuates pathophysiologic changes in experimental pneumococcal meningitis [19].
• CONCLUSION: Our results demonstrate that nimodipine decreases the intracranial pressure during experimental pneumococcal meningitis, possibly by mechanisms including the reduction of ROS and interleukin-6 production [20].

Anatomical context of Meningitis, Pneumococcal

• Cerebrospinal fluid protein profile in experimental pneumococcal meningitis and its alteration by ampicillin and anti-inflammatory agents [21].
• Urokinase-type plasminogen activator receptor regulates leukocyte recruitment during experimental pneumococcal meningitis [22].
• To determine the evolution of these changes and establish the locus of abnormal metabolism during meningitis, glucose and lactate concentrations in brain interstitial fluid, CSF, and serum were measured simultaneously and sequentially during experimental pneumococcal meningitis in rabbits [23].
• Parameters of inflammation during pneumococcal meningitis were determined in rabbits after monocyte elimination by dichloromethylene diphosphonate (Cl(2)MDP)-containing mannosylated liposomes in comparison with untreated controls [24].

Gene context of Meningitis, Pneumococcal

• Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis [25].
• The aim of the study was to determine the differential expression of nitric oxide (NO) synthase (NOS) isoforms and the pathophysiologic relevance of inducible NOS (iNOS) in experimental pneumococcal meningitis [26].
• Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis [27].
• These results indicate that Fas and FasL are not essential in the regulation of the acute inflammatory response during pneumococcal meningitis [28].
• Endothelin B receptor-mediated increase of cerebral blood flow in experimental pneumococcal meningitis [29].

Analytical, diagnostic and therapeutic context of Meningitis, Pneumococcal

• Study investigates the role of endothelin (ET) receptors in mediating early changes in cerebral blood flow--as measured by laser Doppler flowmetry (CBFLDF)--during experimental pneumococcal meningitis [29].
• The therapeutic efficacy of clinafloxacin, a fluoroquinolone in clinical trials, was compared with that of ciprofloxacin and ceftriaxone in a novel pneumococcal meningitis mouse model [30].
• CONCLUSION: Tetraplegia during the course of pneumococcal meningitis in an 11-y-old girl disappeared after treatment with ceftriaxone, erythromycin and dexamethasone [31].
• We report a case of a 71-year-old female with a pneumococcal meningitis treated with extra-corporeal filtration of cerebrospinal fluid (CSF) after 3 days of coma on conventional treatment [32].
• We further demonstrated that the individual prognosis of pneumococcal meningitis could be accurately predicted with only 4 variables and highlighted the preeminent prognostic value of Glasgow coma scale score [33].

References