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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.

The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of- function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.[1]

References

  1. Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. Bischoff, V., Vignal, C., Boneca, I.G., Michel, T., Hoffmann, J.A., Royet, J. Nat. Immunol. (2004) [Pubmed]
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