The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GNBP1  -  Gram-negative bacteria binding protein 1

Drosophila melanogaster

Synonyms: CG6895, DGNBP-1, DGNBP1, Dmel\CG6895, GNBP, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GNBP1


High impact information on GNBP1


Biological context of GNBP1


Anatomical context of GNBP1

  • High hydrostatic pressure (HHP)-mediated solubilization and refolding of five inclusion bodies (IBs) produced from bacteria, three gram-negative binding proteins (GNBP1, GNBP2, and GNBP3) from Drosophila, and two phosphatases from human were investigated in combination of a redox-shuffling agent (2 mM DTT and 6 mM GSSG) and various additives [7].

Associations of GNBP1 with chemical compounds

  • DGNBP-1 has a high affinity to microbial immune elicitors such as lipopolysaccharide (LPS) and beta-1,3-glucan whereas no binding affinity is detected with peptidoglycan, beta-1,4-glucan, or chitin [3].

Other interactions of GNBP1


Analytical, diagnostic and therapeutic context of GNBP1


  1. Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors. Gottar, M., Gobert, V., Matskevich, A.A., Reichhart, J.M., Wang, C., Butt, T.M., Belvin, M., Hoffmann, J.A., Ferrandon, D. Cell (2006) [Pubmed]
  2. In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults. Pili-Floury, S., Leulier, F., Takahashi, K., Saigo, K., Samain, E., Ueda, R., Lemaitre, B. J. Biol. Chem. (2004) [Pubmed]
  3. Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells. Kim, Y.S., Ryu, J.H., Han, S.J., Choi, K.H., Nam, K.B., Jang, I.H., Lemaitre, B., Brey, P.T., Lee, W.J. J. Biol. Chem. (2000) [Pubmed]
  4. Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. Bischoff, V., Vignal, C., Boneca, I.G., Michel, T., Hoffmann, J.A., Royet, J. Nat. Immunol. (2004) [Pubmed]
  5. Purification and molecular cloning of an inducible gram-negative bacteria-binding protein from the silkworm, Bombyx mori. Lee, W.J., Lee, J.D., Kravchenko, V.V., Ulevitch, R.J., Brey, P.T. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  6. Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway. Filipe, S.R., Tomasz, A., Ligoxygakis, P. EMBO Rep. (2005) [Pubmed]
  7. Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Lee, S.H., Carpenter, J.F., Chang, B.S., Randolph, T.W., Kim, Y.S. Protein Sci. (2006) [Pubmed]
  8. Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Gobert, V., Gottar, M., Matskevich, A.A., Rutschmann, S., Royet, J., Belvin, M., Hoffmann, J.A., Ferrandon, D. Science (2003) [Pubmed]
  9. Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA. Wang, L., Weber, A.N., Atilano, M.L., Filipe, S.R., Gay, N.J., Ligoxygakis, P. EMBO J. (2006) [Pubmed]
  10. Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation. Kambris, Z., Brun, S., Jang, I.H., Nam, H.J., Romeo, Y., Takahashi, K., Lee, W.J., Ueda, R., Lemaitre, B. Curr. Biol. (2006) [Pubmed]
WikiGenes - Universities