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Booth, S.L. et al.

Booth, Broe, Peterson, Cheng, Dawson-Hughes, Gundberg, Cupples, Wilson, Kiel,

Associations between vitamin K biochemical measures and bone mineral density in men and women.

Few data exist on the association between vitamin K status and bone mineral density (BMD) in men and women of varying ages. We examined cross-sectional associations between biochemical measures of vitamin K status and BMD at the hip and spine in 741 men and 863 women (mean age, 59 yr; range, 32-86 yr) who participated in the Framingham Heart Study (1996-2000). Vitamin K status was assessed by plasma phylloquinone and percentage undercarboxylated osteocalcin (%ucOC). Among the men, low plasma phylloquinone concentrations adjusted for triglycerides and elevated serum %ucOC levels were associated with low BMD at the femoral neck (P = 0.03 and 0.009, respectively). Among postmenopausal women not using estrogen replacements, low plasma phylloquinone concentrations were associated with low spine BMD (P = 0.007), with a nonsignificant trend of an elevated serum %ucOC with low spine BMD (P = 0.08). In contrast, there were no significant associations between biochemical measures of vitamin K and BMD in either premenopausal women or postmenopausal women using estrogen replacements. Clinical trials are required to isolate any putative effects of vitamin K on rates of bone loss. The target population in these trials, particularly in regard to estrogen use, may be critical, as suggested by the findings of this study.[1]

References

Associations between vitamin K biochemical measures and bone mineral density in men and women. Booth, S.L., Broe, K.E., Peterson, J.W., Cheng, D.M., Dawson-Hughes, B., Gundberg, C.M., Cupples, L.A., Wilson, P.W., Kiel, D.P. J. Clin. Endocrinol. Metab. (2004) [Pubmed]

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