The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Health Services Needs and Demand

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Health Services Needs and Demand


Psychiatry related information on Health Services Needs and Demand


High impact information on Health Services Needs and Demand

  • Knowledge of CF in the sample of non-carriers has also increased after testing, suggesting screening may improve understanding of CF among the entire target population [8].
  • TARGET POPULATION: Patients 50 years of age with newly diagnosed type 2 diabetes (fasting plasma glucose level > or = 7.8 mmol/L [140 mg/dL]) [9].
  • There is therefore an important need to develop new strategies that will allow effectively transduced primitive hematopoietic target populations to be both rapidly characterized and isolated free of residual nontransduced but biologically equivalent cells [10].
  • In addition, the inhibitory effects of IL-4 was also seen in serum-free cultures and in cultures containing highly enriched CD34+, HLA-DR+ cells as a target population [11].
  • However, both GCT-CM and PHA-LCM produced in the presence of hydrocortisone stimulated significantly fewer CFU-Eos in both unfractionated and accessory cell-depleted marrow target populations [12].

Chemical compound and disease context of Health Services Needs and Demand

  • Conversely, on the basis of existing data, greater availability of HIV prevention measures attractive to the target population (including especially drug treatment such as methadone maintenance) is likely to be effective and cost-effective [13].
  • The target population for chemoprophylaxis among HIV seropositives includes all Mantoux (PPD) positive individuals who do not have active tuberculosis and could include all PPD negative individuals living in high prevalence region for TB [14].

Biological context of Health Services Needs and Demand

  • Fas ligand (FasL) is a potent proapoptotic type-II transmembrane protein that can cause cell death in Fas+ target populations [15].
  • Interestingly, however, our results demonstrated that enrichment of G(1)/S-phase cells in the target population through the addition of thymidine moderately (approximately 2-fold) increased gene correction compared to cells in other cell cycle phases, including G(0)/G1, G(1), and G(2)/M [16].
  • We used the observed HPRT mutant (variant) frequency (VF) in the studied population and a 4-way first-order interaction statistical model to estimate parameters that describe the influence of exposure, genotypes and the interaction between the two on the HPRT VF in the target population [17].
  • This information may lead to therapies specifically targeting these events in B cell autoimmunity or malignancy and provide a fuller understanding of the appropriate target populations and potential negative consequences of Btk gene therapy in XLA [18].
  • A sample of 120 male cocaine users was recruited from a public health clinic serving the target population in the city of Porto Alegre. The average age of the participants was 29; they averaged less than 8 years of formal education; and less than half (41%) were married [19].

Anatomical context of Health Services Needs and Demand


Associations of Health Services Needs and Demand with chemical compounds

  • HCC surveillance: who is the target population [24]?
  • Our findings suggest that there are target populations in which supplementary L-arginine may be of therapeutic benefit in the amelioration of microvascular endothelial dysfunction [25].
  • In the initial part of the study, a questionnaire and skin-prick tests with latex and common inhalant allergens were administered to 273 of 289 (94%) members of the target population [26].
  • Mortality rates at the final follow-up of 28 days for placebo, lubeluzole 10 mg/d, and lubeluzole 20 mg/d were, respectively, 18%, 6%, and 35% in the target population, results that were confirmed in the intent-to-treat population [20].
  • The target population in these trials, particularly in regard to estrogen use, may be critical, as suggested by the findings of this study [27].

Gene context of Health Services Needs and Demand

  • However, IL-4 showed weak but significant BPA when peripheral blood (PB)-derived CD34+c-kit(low) cells were used as the target population [28].
  • We found an excess of intermediate alleles for both FRAXA and FRAXE in the target population, but it did not reach statistically significant difference [29].
  • The results of our experiments suggest that the mechanism of induction of TNF-alpha production by IFN-gamma or LPS, and the ultimate autocrine contribution of such TNF-alpha to a given activation response, is dependent on the activated macrophage target population under analysis [30].
  • TARGET POPULATION: Unaffected carriers of a single BRCA1 or BRCA2 mutation 35 to 50 years of age [31].
  • These data suggest that acute phase levels of CRP may have divergent effects depending on the target population [32].

Analytical, diagnostic and therapeutic context of Health Services Needs and Demand


  1. Carnitine-related alterations in patients with intermittent claudication: indication for a focused carnitine therapy. Brevetti, G., di Lisa, F., Perna, S., Menabó, R., Barbato, R., Martone, V.D., Siliprandi, N. Circulation (1996) [Pubmed]
  2. Sepsis and mediator-directed therapy: rethinking the target populations. Mediator-directed therapy in sepsis: rethinking the target populations. Toronto, Canada, 31 October-1 November 1998. Abraham, E., Marshall, J.C. Molecular medicine today. (1999) [Pubmed]
  3. The results of a phase II randomized trial comparing 5-fluorouracil and 5-fluorouracil plus alpha-interferon: observations on the design of clinical trials for androgen-independent prostate cancer. Daliani, D.D., Eisenberg, P.D., Weems, J., Lord, R., Fueger, R., Logothetis, C.J. J. Urol. (1995) [Pubmed]
  4. Thrombocytopenia in liver disease. Peck-Radosavljevic, M. Can. J. Gastroenterol. (2000) [Pubmed]
  5. Evaluation of genotype data in clinical risk assessment: methods and application to BRCA1, BRCA2, and N-acetyl transferase-2 genotypes in breast cancer. Rebbeck, T.R., Rogatko, A., Viana, M.A. Genet. Test. (1997) [Pubmed]
  6. The cost-effectiveness of sildenafil. Smith, K.J., Roberts, M.S. Ann. Intern. Med. (2000) [Pubmed]
  7. Dietary assessment of an educated young Spanish population using a self-administered meal-based food frequency questionnaire. Fregapane, G., Asensio-García, C. Eur. J. Epidemiol. (2000) [Pubmed]
  8. Psychological and social consequences of community carrier screening programme for cystic fibrosis. Watson, E.K., Mayall, E.S., Lamb, J., Chapple, J., Williamson, R. Lancet (1992) [Pubmed]
  9. The cost-effectiveness of treating all patients with type 2 diabetes with angiotensin-converting enzyme inhibitors. Golan, L., Birkmeyer, J.D., Welch, H.G. Ann. Intern. Med. (1999) [Pubmed]
  10. Rapid and efficient selection of human hematopoietic cells expressing murine heat-stable antigen as an indicator of retroviral-mediated gene transfer. Conneally, E., Bardy, P., Eaves, C.J., Thomas, T., Chappel, S., Shpall, E.J., Humphries, R.K. Blood (1996) [Pubmed]
  11. Human interleukin-4 inhibits proliferation of megakaryocyte progenitor cells in culture. Sonoda, Y., Kuzuyama, Y., Tanaka, S., Yokota, S., Maekawa, T., Clark, S.C., Abe, T. Blood (1993) [Pubmed]
  12. Modulation of in vitro eosinophil progenitors by hydrocortisone: role of accessory cells and interleukins. Slovick, F.T., Abboud, C.N., Brennan, J.K., Lichtman, M.A. Blood (1985) [Pubmed]
  13. Taming demons: the reduction of harm resulting from use of illicit drugs. Wodak, A. Australian and New Zealand journal of medicine. (1992) [Pubmed]
  14. Preventive therapy for tuberculosis in HIV infected individuals. Padmapriyadarsini, C., Swaminathan, S. Indian J. Med. Res. (2005) [Pubmed]
  15. Fas ligand engagement of resident peritoneal macrophages in vivo induces apoptosis and the production of neutrophil chemotactic factors. Hohlbaum, A.M., Gregory, M.S., Ju, S.T., Marshak-Rothstein, A. J. Immunol. (2001) [Pubmed]
  16. Targeted correction of single-base-pair mutations with adeno-associated virus vectors under nonselective conditions. Liu, X., Yan, Z., Luo, M., Zak, R., Li, Z., Driskell, R.R., Huang, Y., Tran, N., Engelhardt, J.F. J. Virol. (2004) [Pubmed]
  17. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1). Abdel-Rahman, S.Z., Ammenheuser, M.M., Omiecinski, C.J., Wickliffe, J.K., Rosenblatt, J.I., Ward, J.B. Toxicol. Sci. (2005) [Pubmed]
  18. Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function. Rawlings, D.J. Clin. Immunol. (1999) [Pubmed]
  19. Tailoring an HIV-prevention intervention for cocaine injectors and crack users in Porto Alegre, Brazil. Leukefeld, C.G., Pechansky, F., Martin, S.S., Surratt, H.L., Inciardi, J.A., Kessler, F.H., Orsi, M.M., Von Diemen, L., Meyer Da Silva, E. AIDS care. (2005) [Pubmed]
  20. Lubeluzole in acute ischemic stroke. A double-blind, placebo-controlled phase II trial. Lubeluzole International Study Group. Diener, H.C., Hacke, W., Hennerici, M., Rådberg, J., Hantson, L., De Keyser, J. Stroke (1996) [Pubmed]
  21. Instruction of naive CD4+ T cells by polarized CD4+ T cells within dendritic cell clusters. Creusot, R.J., Biswas, J.S., Thomsen, L.L., Tite, J.P., Mitchison, N.A., Chain, B.M. Eur. J. Immunol. (2003) [Pubmed]
  22. Differential sensitivity of mouse neural crest cells to ethanol-induced toxicity. Chen, S.Y., Periasamy, A., Yang, B., Herman, B., Jacobson, K., Sulik, K.K. Alcohol (2000) [Pubmed]
  23. The target population in phase I clinical trials of cholinergic compounds in Alzheimer disease: the role of the "bridging study". Cutler, N.R., Sramek, J.J. Alzheimer disease and associated disorders. (1995) [Pubmed]
  24. HCC surveillance: who is the target population? Bruix, J., Llovet, J.M. Hepatology (2003) [Pubmed]
  25. The presence of African American race predicts improvement in coronary endothelial function after supplementary L-arginine. Houghton, J.L., Philbin, E.F., Strogatz, D.S., Torosoff, M.T., Fein, S.A., Kuhner, P.A., Smith, V.E., Carr, A.A. J. Am. Coll. Cardiol. (2002) [Pubmed]
  26. Prevalence of occupational asthma due to latex among hospital personnel. Vandenplas, O., Delwiche, J.P., Evrard, G., Aimont, P., van der Brempt, X., Jamart, J., Delaunois, L. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  27. Associations between vitamin K biochemical measures and bone mineral density in men and women. Booth, S.L., Broe, K.E., Peterson, J.W., Cheng, D.M., Dawson-Hughes, B., Gundberg, C.M., Cupples, L.A., Wilson, P.W., Kiel, D.P. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  28. Action of human interleukin-4 and stem cell factor on erythroid and mixed colony formation by peripheral blood-derived CD34+ c-kit(high) or CD34+ c-kit(low) cells. Sonoda, Y., Kimura, T., Ohmizono, Y., Sakabe, H., Tanimukai, S., Yokota, S., Clark, S.C., Abe, T. Br. J. Haematol. (1997) [Pubmed]
  29. The influence of expanded unmethylated alleles for FRAXA/FRAXE loci in the intellectual performance among Brazilian mentally impaired males. Barros Santos, C., Gonçalves Pimentel, M.M. Int. J. Mol. Med. (2003) [Pubmed]
  30. TNF-alpha differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines. Wynn, T.A., Freund, Y.R., Paulnock, D.M. Cell. Immunol. (1992) [Pubmed]
  31. Cost-effectiveness of preventive strategies for women with a BRCA1 or a BRCA2 mutation. Anderson, K., Jacobson, J.S., Heitjan, D.F., Zivin, J.G., Hershman, D., Neugut, A.I., Grann, V.R. Ann. Intern. Med. (2006) [Pubmed]
  32. Acute phase levels of C-reactive protein enhance IL-1 beta and IL-1ra production by human blood monocytes but inhibit IL-1 beta and IL-1ra production by alveolar macrophages. Pue, C.A., Mortensen, R.F., Marsh, C.B., Pope, H.A., Wewers, M.D. J. Immunol. (1996) [Pubmed]
  33. Tuberculosis in renal transplant recipients. Sayiner, A., Ece, T., Duman, S., Yildiz, A., Ozkahya, M., Kiliçaslan, Z., Tokat, Y. Transplantation (1999) [Pubmed]
  34. Screen for MAOA mutations in target human groups. Schuback, D.E., Mulligan, E.L., Sims, K.B., Tivol, E.A., Greenberg, B.D., Chang, S.F., Yang, S.L., Mau, Y.C., Shen, C.Y., Ho, M.S., Yang, N.H., Butler, M.G., Fink, S., Schwartz, C.E., Berlin, F., Breakefield, X.O., Murphy, D.L., Hsu, Y.P. Am. J. Med. Genet. (1999) [Pubmed]
  35. Vitamin C concentrations in plasma as a function of intake: a meta-analysis. Brubacher, D., Moser, U., Jordan, P. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (2000) [Pubmed]
  36. Impact of population-based selective chemotherapy on prevalence and intensity of Schistosoma mansoni infections in the Nile Delta: Kafr El Sheikh. Barakat, R., el Masry, A.G., Farghaly, A., el Morshidy, H.N., elSayed, M.K., Husein, M.H., Miller, F.D. Tropical and geographical medicine. (1995) [Pubmed]
WikiGenes - Universities