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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor.

Baclofen was administered to rats systemically (intraperitoneal, i.p.) by itself or with L-NAME. Baclofen (1-7.5 mg/kg, i.p.) evoked dose-dependent hypothermia. L-NAME (50 mg/kg, i.p.) was ineffective. For combined administration, L-NAME increased the relative potency of baclofen (F=10.77, p<0.05), indicating multiplicative interaction and synergism. The present data reveal a surprising and significant interaction between nitric oxide synthase (NOS) and baclofen-induced hypothermia.[1]

References

  1. Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor. Rawls, S.M., Baron, D.A., Gomez, T., Jacobs, K., Tallarida, R.J. Eur. J. Pharmacol. (2004) [Pubmed]
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