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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor.

Baclofen was administered to rats systemically (intraperitoneal, i.p.) by itself or with L-NAME. Baclofen (1-7.5 mg/kg, i.p.) evoked dose-dependent hypothermia. L-NAME (50 mg/kg, i.p.) was ineffective. For combined administration, L-NAME increased the relative potency of baclofen (F=10.77, p<0.05), indicating multiplicative interaction and synergism. The present data reveal a surprising and significant interaction between nitric oxide synthase (NOS) and baclofen-induced hypothermia.[1]


  1. Pronounced hypothermic synergy between systemic baclofen and NOS inhibitor. Rawls, S.M., Baron, D.A., Gomez, T., Jacobs, K., Tallarida, R.J. Eur. J. Pharmacol. (2004) [Pubmed]
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