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MeSH Review


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Disease relevance of Hypothermia


Psychiatry related information on Hypothermia


High impact information on Hypothermia

  • Hypothermia did not improve the outcomes in the patients with coma scores of 3 or 4 on admission [1].
  • Prevention of doxorubicin-induced hair loss with scalp hypothermia [11].
  • Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin [12].
  • Ethanol-induced intoxication and hypothermia were studied in rats approximately 7 months after severe thiamine deficiency, when treated rats appeared to have recovered their physical health [13].
  • Calcium, other divalent cations, and calcium antagonists were tested for their ability to alter ethanol-induced sleeping time, hypothermia, and behavioral intoxication in mice and rats [14].

Chemical compound and disease context of Hypothermia


Biological context of Hypothermia


Anatomical context of Hypothermia

  • Thus, hyperosmolarity, but not hypothermia, can directly stimulate tachykinin release from cultured rat sensory C-fibers [23].
  • Calcium depletion in rabbit myocardium. Calcium paradox protection by hypothermia and cation substitution [24].
  • These findings suggest that: 1) mild hypothermia is an effective approach to the prevention of the central nervous system consequences of experimental ALF; and that 2) the beneficial effect of hypothermia is mediated via mechanisms involving reduced blood-brain transfer of ammonia and/or reduction of extracellular brain glutamate concentrations [25].
  • Different effects of hypothermia on insulin and glucagon secretion from the isolated perfused rat pancreas [26].
  • Pretreatment with a single injection of MK-801 (10 mg/kg) considerably attenuated the induction of hsp70 mRNA in hippocampus at 6 h of recirculation, an effect apparently mediated by persistent drug-induced hypothermia [27].

Gene context of Hypothermia

  • Inasmuch as Rbm3 mRNA and protein levels are both increased in cells exposed to mild hypothermia, the activity of this IRES was evaluated at a cooler temperature [28].
  • Increased activation of BDNF signaling is a possible mechanism by which mild hypothermia is able to reduce the neuronal damage typically occurring after cardiac arrest [29].
  • The clinical manifestation with weight loss, hypothermia, hypoglycemia, hyperkalemia, and increased liver-derived enzymes in the blood together with hepatic necrosis and intravascular coagulation in moribund mice indicated a toxic shock-like syndrome, possibly mediated by the systemic TNF-alpha overproduction [30].
  • The data suggest that TVX Q 7821 is a good presynaptic 5-HT1A antagonist in mice, as indicated by the 8-OH-DPAT-induced hypothermia and 5-HT synthesis rate studies [31].
  • In rats the hypothermia induced by 8-OH-DPAT was partially antagonised by TVX Q 7821 while the behavioural "serotonin syndrome" induced by 8-OH-DPAT (a possible post-synaptic 5-HT1B-mediated effect) was unaffected by TVX Q 7821 as was the locomotion induced by RU 24969 [31].

Analytical, diagnostic and therapeutic context of Hypothermia


  1. Treatment of traumatic brain injury with moderate hypothermia. Marion, D.W., Penrod, L.E., Kelsey, S.F., Obrist, W.D., Kochanek, P.M., Palmer, A.M., Wisniewski, S.R., DeKosky, S.T. N. Engl. J. Med. (1997) [Pubmed]
  2. Influence of scalp hypothermia on doxorubicin related alopecia. Timothy, A.R., Bates, T.D., Hoy, A.M. Lancet (1980) [Pubmed]
  3. Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study. Chatauret, N., Zwingmann, C., Rose, C., Leibfritz, D., Butterworth, R.F. Gastroenterology (2003) [Pubmed]
  4. Cardiopulmonary arrest. Pathophysiology and neurologic complications. Bass, E. Ann. Intern. Med. (1985) [Pubmed]
  5. Bretylium tosylate and ventricular fibrillation in hypothermia. Kochar, G., Kahn, S.E., Kotler, M.N. Ann. Intern. Med. (1986) [Pubmed]
  6. The central action of pizotifen. Przegaliński, E., Baran, L., Palider, W., Siwanowicz, J. Psychopharmacology (Berl.) (1979) [Pubmed]
  7. Changes in the behavioural response to a TRH analogue following chronic amitriptyline treatment and repeated electroconvulsive shock in the rat. Bennett, G.W., Green, A.R., Lighton, C., Marsden, C.A. Br. J. Pharmacol. (1986) [Pubmed]
  8. Cannabis, catecholamines, rapid eye movement sleep and aggressive behaviour. Carlini, E.A., Lindsey, C.J., Tufik, S. Br. J. Pharmacol. (1977) [Pubmed]
  9. Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. McGregor, I.S., Gurtman, C.G., Morley, K.C., Clemens, K.J., Blokland, A., Li, K.M., Cornish, J.L., Hunt, G.E. Psychopharmacology (Berl.) (2003) [Pubmed]
  10. Antidepressant profile in rodents of SR 58611A, a new selective agonist for atypical beta-adrenoceptors. Simiand, J., Keane, P.E., Guitard, J., Langlois, X., Gonalons, N., Martin, P., Bianchetti, A., Le Fur, G., Soubrié, P. Eur. J. Pharmacol. (1992) [Pubmed]
  11. Prevention of doxorubicin-induced hair loss with scalp hypothermia. Dean, J.C., Salmon, S.E., Griffith, K.S. N. Engl. J. Med. (1979) [Pubmed]
  12. Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin. Bissette, G., Nemeroff, C.B., Loosen, P.T., Prange, A.J., Lipton, M.A. Nature (1976) [Pubmed]
  13. Response to ethanol reduced by past thiamine deficiency. Martin, P.R., Majchrowicz, E., Tamborska, E., Marietta, C., Mukherjee, A.B., Eckardt, M.J. Science (1985) [Pubmed]
  14. Ethanol: modifications of acute intoxication by divalent cations. Erickson, C.K., Tyler, T.D., Harris, R.A. Science (1978) [Pubmed]
  15. Brain noradrenergic systems as a prerequisite for developing tolerance to barbiturates. Tabakoff, B., Yanai, J., Ritzmann, R.F. Science (1978) [Pubmed]
  16. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Gainetdinov, R.R., Bohn, L.M., Walker, J.K., Laporte, S.A., Macrae, A.D., Caron, M.G., Lefkowitz, R.J., Premont, R.T. Neuron (1999) [Pubmed]
  17. Urea secretion by the straight segment of the proximal tubule. Kawamura, S., Kokko, J.P. J. Clin. Invest. (1976) [Pubmed]
  18. No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Hedlund, P.B., Danielson, P.E., Thomas, E.A., Slanina, K., Carson, M.J., Sutcliffe, J.G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  19. Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia. Colbourne, F., Grooms, S.Y., Zukin, R.S., Buchan, A.M., Bennett, M.V. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  20. Purkinje repolarization as a possible cause of the U wave in the electrocardiogram. Watanabe, Y. Circulation (1975) [Pubmed]
  21. Central vasopressin infusion prevents hibernation in the European hamster (Cricetus cricetus). Hermes, M.L., Buijs, R.M., Masson-Pévet, M., van der Woude, T.P., Pévet, P., Brenklé, R., Kirsch, R. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  22. Hypothermia during cardiopulmonary bypass delays but does not prevent neutrophil-endothelial cell adhesion. A clinical study. Le Deist, F., Menasché, P., Kucharski, C., Bel, A., Piwnica, A., Bloch, G. Circulation (1995) [Pubmed]
  23. Hypertonicity, but not hypothermia, elicits substance P release from rat C-fiber neurons in primary culture. Garland, A., Jordan, J.E., Necheles, J., Alger, L.E., Scully, M.M., Miller, R.J., Ray, D.W., White, S.R., Solway, J. J. Clin. Invest. (1995) [Pubmed]
  24. Calcium depletion in rabbit myocardium. Calcium paradox protection by hypothermia and cation substitution. Rich, T.L., Langer, G.A. Circ. Res. (1982) [Pubmed]
  25. Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure. Rose, C., Michalak, A., Pannunzio, M., Chatauret, N., Rambaldi, A., Butterworth, R.F. Hepatology (2000) [Pubmed]
  26. Different effects of hypothermia on insulin and glucagon secretion from the isolated perfused rat pancreas. Loubatières-Mariani, M.M., Chapal, J., Puech, R., Lignon, F., Valette, G. Diabetologia (1980) [Pubmed]
  27. Localization of 70 kDa stress protein mRNA induction in gerbil brain after ischemia. Nowak, T.S. J. Cereb. Blood Flow Metab. (1991) [Pubmed]
  28. A 5' Leader of Rbm3, a Cold Stress-induced mRNA, Mediates Internal Initiation of Translation with Increased Efficiency under Conditions of Mild Hypothermia. Chappell, S.A., Owens, G.C., Mauro, V.P. J. Biol. Chem. (2001) [Pubmed]
  29. Hypothermic reperfusion after cardiac arrest augments brain-derived neurotrophic factor activation. D'Cruz, B.J., Fertig, K.C., Filiano, A.J., Hicks, S.D., DeFranco, D.B., Callaway, C.W. J. Cereb. Blood Flow Metab. (2002) [Pubmed]
  30. Tumor necrosis factor alpha-mediated toxic shock in Trypanosoma cruzi-infected interleukin 10-deficient mice. Hölscher, C., Mohrs, M., Dai, W.J., Köhler, G., Ryffel, B., Schaub, G.A., Mossmann, H., Brombacher, F. Infect. Immun. (2000) [Pubmed]
  31. The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats. Goodwin, G.M., De Souza, R.J., Green, A.R. Psychopharmacology (Berl.) (1986) [Pubmed]
  32. Emergency treatment of neonatal hyperammonaemic coma with mild systemic hypothermia. Whitelaw, A., Bridges, S., Leaf, A., Evans, D. Lancet (2001) [Pubmed]
  33. Increased circulating bradykinin during hypothermia and cardiopulmonary bypass in children. Pang, L.M., Stalcup, S.A., Lipset, J.S., Hayes, C.J., Bowman, F.O., Mellins, R.B. Circulation (1979) [Pubmed]
  34. Comparison of myocardial protection with nifedipine and potassium. Magee, P.G., Flaherty, J.T., Bixler, T.J., Glower, D., Gardner, T.J., Bukley, B.H., Gott, V.L. Circulation (1979) [Pubmed]
  35. Parallel temperature dependence of contracture-associated enzyme release due to anoxia, 2,4-dinitrophenol (DNP), or caffeine and the calcium paradox. Ganote, C.E., Sims, M.A. Am. J. Pathol. (1984) [Pubmed]
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