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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Golding, J.P. et al.

Golding, Partridge, Beauchamp, King, Brown, Gassmann, Zammit,

Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin.

Most muscle originates from the myotomal compartment of the somites, paired structures flanking the neural tube. Whereas vertebrate embryos show molecular and morphological asymmetry about the left-right body axis, somitic myogenesis is thought to occur symmetrically. Here, we provide the first evidence that myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25. In iv mutants with situs inversus, the asymmetric expression of alpha-skeletal actin and MLC3F was inverted, showing that this process is regulated by global left-right axis cues, initiated before gastrulation. However, although left-sided identity is later maintained by Pitx2 genes, we found that Pitx2c null embryos have normal left-biased expression of alpha-skeletal actin and MLC3F. Myotome asymmetry, therefore, is downstream of the iv mutation but upstream of, or unrelated to, the Pitx2c pathway.[1]

References

Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin. Golding, J.P., Partridge, T.A., Beauchamp, J.R., King, T., Brown, N.A., Gassmann, M., Zammit, P.S. Dev. Dyn. (2004) [Pubmed]

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