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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Johansen, J.S. et al.

Johansen, Drivsholm, Price, Christensen,

High serum YKL-40 level in patients with small cell lung cancer is related to early death.

YKL-40, a growth factor for connective tissue cells, is secreted by cancer cells and macrophages. Elevated serum YKL-40 in patients with metastatic carcinoma has been associated with poor prognosis. We evaluated serum YKL-40 in 131 patients with small cell lung cancer (SCLC). Twenty-two percent of the patients with limited disease and 40% of the patients with extensive disease had elevated serum YKL-40. The median survival was 5.1 months for patients with elevated serum YKL-40 and 9.0 months for patients with normal serum YKL-40. Patients with elevated serum YKL-40 had increased hazard for death within the first 6 months after the start of chemotherapy compared to patients with normal serum YKL-40 (HR = 2.06, P = 0.009). Multivariate Cox analysis including routine prognostic variables showed that serum YKL-40 (P = 0.02) is independent of prognostic variables for survival within the first 6 months. Studies are needed to determine the function of YKL-40 in SCLC.[1]

References

High serum YKL-40 level in patients with small cell lung cancer is related to early death. Johansen, J.S., Drivsholm, L., Price, P.A., Christensen, I.J. Lung Cancer (2004) [Pubmed]

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