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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Immunological prevention of a multigene cancer syndrome.

Vaccines effectively prevent the onset of tumors in transgenic mice carrying activated oncogenes; however, human tumors are caused by combined alterations in oncogenes and oncosuppressor genes. We evaluated the impact of prophylactic vaccines in HER-2/neu transgenic, p53 wild-type/null mice that succumb to an aggressive cancer syndrome comprising mammary and salivary gland carcinomas and rhabdomyosarcoma. A vaccine made of allogeneic mammary carcinoma cells expressing HER-2/neu and interleukin 12 afforded long-term protection from tumor onset. Tumor prevention was mediated by T cell-derived cytokines, in particular gamma-interferon, and by anti-HER-2/neu antibodies. HER-2/neu expression was inhibited in target tissues of vaccinated mice, and somatic loss of the wild-type p53 allele did not occur. A highly effective vaccine against a single oncoprotein induced a powerful immune response that arrested multistep carcinogenesis in distinct target tissues.[1]


  1. Immunological prevention of a multigene cancer syndrome. Croci, S., Nicoletti, G., Landuzzi, L., De Giovanni, C., Astolfi, A., Marini, C., Di Carlo, E., Musiani, P., Forni, G., Nanni, P., Lollini, P.L. Cancer Res. (2004) [Pubmed]
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