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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A fibrinogen-binding protein of Staphylococcus lugdunensis.

A gene called fbl, encoding a Staphylococcus lugdunensis fibrinogen-binding protein, was identified by phage display. The encoded protein, Fbl, is a member of the Sdr-family, a group of staphylococcal cell surface proteins containing a characteristic serine-aspartate repeat region. The fibrinogen-binding domain was mapped to 313 amino acids, and shows 62% identity to the corresponding region in clumping factor (ClfA) from Staphylococcus aureus. Anti-serum against ClfA cross-reacted with Fbl, and blocked S. lugdunensis adherence to fibrinogen. Twelve clinical isolates of S. lugdunensis analysed by Southern blot all had an fbl-like gene.[1]


  1. A fibrinogen-binding protein of Staphylococcus lugdunensis. Nilsson, M., Bjerketorp, J., Guss, B., Frykberg, L. FEMS Microbiol. Lett. (2004) [Pubmed]
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