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Gene Review

fib  -  fibrinogen-binding protein

Staphylococcus aureus RF122

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Disease relevance of fib


High impact information on fib


Biological context of fib


Anatomical context of fib


Associations of fib with chemical compounds


Other interactions of fib

  • In addition to the family of adhesive proteins bound to the cell wall via the sortase A (srtA) mechanism, secreted proteins such as the fibrinogen-binding protein Efb, the extracellular adhesion protein Eap, or coagulase have been found to interact with various extracellular host molecules [16].

Analytical, diagnostic and therapeutic context of fib


  1. Multiple binding sites in the interaction between an extracellular fibrinogen-binding protein from Staphylococcus aureus and fibrinogen. Palma, M., Wade, D., Flock, M., Flock, J.I. J. Biol. Chem. (1998) [Pubmed]
  2. Extracellular fibrinogen-binding protein, Efb, from Staphylococcus aureus blocks platelet aggregation due to its binding to the alpha-chain. Palma, M., Shannon, O., Quezada, H.C., Berg, A., Flock, J.I. J. Biol. Chem. (2001) [Pubmed]
  3. A fibrinogen-binding protein of Staphylococcus epidermidis. Nilsson, M., Frykberg, L., Flock, J.I., Pei, L., Lindberg, M., Guss, B. Infect. Immun. (1998) [Pubmed]
  4. Clumping factor A-mediated virulence during Staphylococcus aureus infection is retained despite fibrinogen depletion. Palmqvist, N., Josefsson, E., Tarkowski, A. Microbes Infect. (2004) [Pubmed]
  5. A fibrinogen-binding protein of Staphylococcus lugdunensis. Nilsson, M., Bjerketorp, J., Guss, B., Frykberg, L. FEMS Microbiol. Lett. (2004) [Pubmed]
  6. Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb). Lee, L.Y., Liang, X., Höök, M., Brown, E.L. J. Biol. Chem. (2004) [Pubmed]
  7. Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureus. McDevitt, D., Francois, P., Vaudaux, P., Foster, T.J. Mol. Microbiol. (1994) [Pubmed]
  8. Cloning, expression, and nucleotide sequence of a Staphylococcus aureus gene (fbpA) encoding a fibrinogen-binding protein. Cheung, A.I., Projan, S.J., Edelstein, R.E., Fischetti, V.A. Infect. Immun. (1995) [Pubmed]
  9. Staphylococcus aureus interactions with the endothelium: the role of bacterial "secretable expanded repertoire adhesive molecules" (SERAM) in disturbing host defense systems. Chavakis, T., Wiechmann, K., Preissner, K.T., Herrmann, M. Thromb. Haemost. (2005) [Pubmed]
  10. Antibody responses in patients with staphylococcal septicemia against two Staphylococcus aureus fibrinogen binding proteins: clumping factor and an extracellular fibrinogen binding protein. Colque-Navarro, P., Palma, M., Söderquist, B., Flock, J.I., Möllby, R. Clin. Diagn. Lab. Immunol. (2000) [Pubmed]
  11. Relationship between some Staphylococcus aureus pathogenic factors and growth rates and somatic cell counts. Zecconi, A., Binda, E., Borromeo, V., Piccinini, R. J. Dairy Res. (2005) [Pubmed]
  12. Staphylococcus aureus induces platelet aggregation via a fibrinogen-dependent mechanism which is independent of principal platelet glycoprotein IIb/IIIa fibrinogen-binding domains. Bayer, A.S., Sullam, P.M., Ramos, M., Li, C., Cheung, A.L., Yeaman, M.R. Infect. Immun. (1995) [Pubmed]
  13. Biochemical properties of fibrinogen binding protein (clumping factor) of the staphylococcal cell surface. Usui, Y. Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. (1986) [Pubmed]
  14. Nucleotide substitution and recombination at orthologous loci in Staphylococcus aureus. Hughes, A.L., Friedman, R. J. Bacteriol. (2005) [Pubmed]
  15. Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain Newman. Bodén, M.K., Flock, J.I. Microb. Pathog. (1992) [Pubmed]
  16. Identification and characterization of a novel 38.5-kilodalton cell surface protein of Staphylococcus aureus with extended-spectrum binding activity for extracellular matrix and plasma proteins. Hussain, M., Becker, K., von Eiff, C., Schrenzel, J., Peters, G., Herrmann, M. J. Bacteriol. (2001) [Pubmed]
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