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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The febrile response to intraperitoneal lipopolysaccharide: strain and gender differences in rats.

The acute-phase febrile responses of the inbred Lewis (LEW) and Fischer 344 (F344) rat strains and their parent Sprague-Dawley (S-D) strain to immune challenge with lipopolysaccharide (LPS) were compared. LEW and S-D males and females displayed a biphasic febrile response with a markedly attenuated second phase in F344 rats. At 2 h after LPS (50 microg/kg), corticosterone was significantly higher in F344 than in LEW rats, but serum interleukin-1beta was higher only in F344 than LEW males. These data suggest that the greater LPS-induced corticosterone response of F344 rats mediates differences between febrile responses of F344 and LEW males and females.[1]

References

  1. The febrile response to intraperitoneal lipopolysaccharide: strain and gender differences in rats. Taylor, A.N., Tio, D.L., Romeo, H.E. J. Neuroimmunol. (2005) [Pubmed]
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