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Rats, Inbred Lew

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Disease relevance of Rats, Inbred Lew


Psychiatry related information on Rats, Inbred Lew


High impact information on Rats, Inbred Lew

  • In the present study, we show that CD4+ anti-class II T cells are present in HgCl2-injected LEW rats and are as frequent as in BN rats when assessed by limiting dilution analysis [9].
  • We found that the gene coding for endothelin-2 (ET2), also known as vasoctive intestine peptide, cosegregated strongly with systolic blood pressure in a F2 population [F2(S x LEW)] derived from a cross of the Dahl salt-sensitive (S) rat and the Lewis (LEW/NCrlBR) (LEW) rat [10].
  • Immunodeficient athymic and cyclosporin A-treated LEW rats developed only the early phase arthritis, which was again paralleled by synovial Ia expression [11].
  • The LEW rats, which are resistant to MST cells, might have rejected the tumor on the basis of factors other than Ag-B antigens [12].
  • We have investigated their impact on graft rejection rates in busulfan-treated LEW rats [13].

Chemical compound and disease context of Rats, Inbred Lew


Biological context of Rats, Inbred Lew


Anatomical context of Rats, Inbred Lew

  • We conclude that HgCl2 induces CD4+ autoreactive T cells that proliferate in the presence of class II+ cells in susceptible BN as well as in resistant LEW rats [9].
  • Line vLe, which was derived from Lewis (LEW) rat lymphocytes, and which recognized the encephalitogenic sequence 48-88 of MBP, was extremely efficient in mediating EAE to normal untreated LEW rats [18].
  • Ag-specific lymph node cells from LEW rats produced higher amounts of IL-2 and IFN-gamma than BN lymph node cells, but expressed less IL-4 mRNA [19].
  • Pulse labeling for 30 minutes revealed 8% BrdUrd-positive intravascular ED 1-positive class II-positive monocytes in situ on day 3 of treatment, which contrasted with almost-absent labeling of this cell population in normal LEW rats [20].
  • The renal glomeruli of chlorpromazine-treated LEW rats examined 6 and 48 hr after transfer of anti-brush border antibodies had punctate and, later, punctate and diffuse deposits of sheep (or rabbit) IgG on glomerular epithelial cells, but not similar deposits of rat C3 [21].

Associations of Rats, Inbred Lew with chemical compounds

  • These studies of azaserine-induced AACN provided a basis for selection of carcinogenic azaserine regimens and suggested that the young male W/LEW rat was the most sensitive of the animals studied [22].
  • Therefore, we tested these agents in LEW rats receiving a myeloablative dose of busulfan followed by transfer of F1 (CAP X LEW) marrow, which is unable to induce a graft-v-host reaction (GVHR) [23].
  • Neonatal islets of dorsal origin were transplanted intrasplenically (500-3000 islets) to streptozocin-induced diabetic inbred Lewis rats [24].
  • In the present study, we show that a 30-day course of LF 15-0195 treatment not only prevents MBP-immunized LEW rats from developing EAE but also preserves their refractory phase to reinduction of disease [25].
  • Most importantly, pretreatment of LEW rats with the dexamethasone-treated DC led to the indefinite survival of AUG kidney grafts after a short course of cyclosporin to inhibit the early direct pathway response [26].

Gene context of Rats, Inbred Lew


Analytical, diagnostic and therapeutic context of Rats, Inbred Lew


  1. Pathologic and biochemical effects of azaserine in inbred Wistar/Lewis rats and noninbred CD-1 mice. Roebuck, B.D., Lilja, H.S., Curphey, T.J., Longnecker, D.S. J. Natl. Cancer Inst. (1980) [Pubmed]
  2. Effect of N-methyl-N'-nitro-N-nitrosoguanidine on gastroduodenal epithelial proliferation in Wistar/Lewis rats. Quimby, G.F., Eastwood, G.L. J. Natl. Cancer Inst. (1981) [Pubmed]
  3. MHC class II isotype- and allele-specific attenuation of experimental autoimmune encephalomyelitis. de Graaf, K.L., Barth, S., Herrmann, M.M., Storch, M.K., Otto, C., Olsson, T., Melms, A., Jung, G., Wiesmüller, K.H., Weissert, R. J. Immunol. (2004) [Pubmed]
  4. Polyclonal effect of HgCl2 in the rat, its possible role in an experimental autoimmune disease. Hirsch, F., Couderc, J., Sapin, C., Fournie, G., Druet, P. Eur. J. Immunol. (1982) [Pubmed]
  5. Polyclonal IgE increase after HgCl2 injections in BN and LEW rats: a genetic analysis. Sapin, C., Hirsch, F., Delaporte, J.P., Bazin, H., Druet, P. Immunogenetics (1984) [Pubmed]
  6. Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats. Haile, C.N., Hiroi, N., Nestler, E.J., Kosten, T.A. Synapse (2001) [Pubmed]
  7. Effects of sucrose-substitution initiation on patterns of drinking by Lewis rats during continuous alcohol access. Files, F.J., Samson, H.H., Denning, C.E. Alcohol (1997) [Pubmed]
  8. Etonitazene delivered orally serves as a reinforcer for Lewis but not Fischer 344 rats. Suzuki, T., George, F.R., Meisch, R.A. Pharmacol. Biochem. Behav. (1992) [Pubmed]
  9. Mercury-induced autoreactive anti-class II T cell line protects from experimental autoimmune encephalomyelitis by the bias of CD8+ antiergotypic cells in Lewis rats. Castedo, M., Pelletier, L., Rossert, J., Pasquier, R., Villarroya, H., Druet, P. J. Exp. Med. (1993) [Pubmed]
  10. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. Deng, A.Y., Dene, H., Pravenec, M., Rapp, J.P. J. Clin. Invest. (1994) [Pubmed]
  11. Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis. Differences in site and intensity of expression in euthymic, athymic, and cyclosporin A-treated LEW and F344 rats. Wilder, R.L., Allen, J.B., Hansen, C. J. Clin. Invest. (1987) [Pubmed]
  12. Alloantigen expression of a rat Moloney sarcoma. Jones, J.M., Feldman, J.D. J. Natl. Cancer Inst. (1975) [Pubmed]
  13. Influence of cell dose and graft-versus-host reactivity on rejection rates after allogeneic bone marrow transplantation. Uharek, L., Gassmann, W., Glass, B., Steinmann, J., Loeffler, H., Mueller-Ruchholtz, W. Blood (1992) [Pubmed]
  14. Experimental gold-induced autoimmunity. Tournade, H., Guery, J.C., Pasquier, R., Nochy, D., Hinglais, N., Guilbert, B., Druet, P., Pelletier, L. Nephrol. Dial. Transplant. (1991) [Pubmed]
  15. Th1/Th2 cytokine gene expression after mercuric chloride in susceptible and resistant rat strains. Gillespie, K.M., Saoudi, A., Kuhn, J., Whittle, C.J., Druet, P., Bellon, B., Mathieson, P.W. Eur. J. Immunol. (1996) [Pubmed]
  16. Pharmacokinetics of heparin VII: Effect of pregnancy on the relationship between concentration and anticoagulant action of heparin in rats. Whitfield, L.R., Wilkenfeld, C., Levy, G. Journal of pharmaceutical sciences. (1984) [Pubmed]
  17. Antibody response to sheep red blood cells in four substrains of BB rats, some other strains and interstrain F2 hybrids. Klöting, I., Stark, O. Folia Biol. (Praha) (1986) [Pubmed]
  18. Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed rat T lymphocyte populations. Schluesener, H.J., Wekerle, H. J. Immunol. (1985) [Pubmed]
  19. Experimental autoimmune myasthenia gravis may occur in the context of a polarized Th1- or Th2-type immune response in rats. Saoudi, A., Bernard, I., Hoedemaekers, A., Cautain, B., Martinez, K., Druet, P., De Baets, M., Guéry, J.C. J. Immunol. (1999) [Pubmed]
  20. Gamma interferon treatment in vivo provokes accumulation of activated monocytes in the venous circulation of rats. Steiniger, B., Schröder, D., Lück, R., Luciano, L., van der Meide, P.H. Am. J. Pathol. (1990) [Pubmed]
  21. Pathogenesis of passive Heymann glomerulonephritis: chlorpromazine inhibits antibody-mediated redistribution of cell surface antigens and prevents development of the disease. Camussi, G., Noble, B., Van Liew, J., Brentjens, J.R., Andres, G. J. Immunol. (1986) [Pubmed]
  22. Species and rat strain variation in pancreatic nodule induction by azaserine. Roebuck, B.D., Longnecker, D.S. J. Natl. Cancer Inst. (1977) [Pubmed]
  23. Comparison of cyclophosphamide, cytarabine, and etoposide as immunosuppressive agents before allogeneic bone marrow transplantation. Gassmann, W., Uharek, L., Wottge, H.U., Schmitz, N., Löffler, H., Mueller-Ruchholtz, W. Blood (1988) [Pubmed]
  24. Hormone release, islet yield, and transplantation of fetal and neonatal rat dorsal and ventral pancreatic islets. Hayek, A., Guardian, C. Diabetes (1986) [Pubmed]
  25. LF 15-0195 treatment protects against central nervous system autoimmunity by favoring the development of Foxp3-expressing regulatory CD4 T cells. Duplan, V., Beriou, G., Heslan, J.M., Bruand, C., Dutartre, P., Mars, L.T., Liblau, R.S., Cuturi, M.C., Saoudi, A. J. Immunol. (2006) [Pubmed]
  26. Modified dendritic cells coexpressing self and allogeneic major histocompatability complex molecules: an efficient way to induce indirect pathway regulation. Mirenda, V., Berton, I., Read, J., Cook, T., Smith, J., Dorling, A., Lechler, R.I. J. Am. Soc. Nephrol. (2004) [Pubmed]
  27. A comparative study of experimental autoimmune encephalomyelitis in Lewis and DA rats. Stepaniak, J.A., Gould, K.E., Sun, D., Swanborg, R.H. J. Immunol. (1995) [Pubmed]
  28. CD28-B7 T cell costimulatory blockade by CTLA4Ig in sensitized rat recipients: induction of transplantation tolerance in association with depressed cell-mediated and humoral immune responses. Onodera, K., Chandraker, A., Schaub, M., Stadlbauer, T.H., Korom, S., Peach, R., Linsley, P.S., Sayegh, M.H., Kupiec-Weglinski, J.W. J. Immunol. (1997) [Pubmed]
  29. Inconsistent susceptibility to autoimmunity in inbred LEW rats is due to genetic crossbreeding involving segregation of the arthritis-regulating gene Ncf1. Olofsson, P., Johansson, A., Wedekind, D., Klöting, I., Klinga-Levan, K., Lu, S., Holmdahl, R. Genomics (2004) [Pubmed]
  30. Does the rat have an H2-D orthologue next to Bat1? Lambracht-Washington, D., Fischer Lindahl, K. Immunogenetics (2002) [Pubmed]
  31. Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and Lewis rats. Alam, I., Sun, Q., Liu, L., Koller, D.L., Fishburn, T., Carr, L.G., Econs, M.J., Foroud, T., Turner, C.H. J. Bone Miner. Res. (2005) [Pubmed]
  32. Inhibition of endothelin-converting enzyme attenuates transplant vasculopathy and rejection in rat cardiac allografts. Simonson, M.S., Herman, W.H., Robinson, A., Schulak, J., Hricik, D.E. Transplantation (1999) [Pubmed]
  33. Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis. Oitzl, M.S., van Haarst, A.D., Sutanto, W., de Kloet, E.R. Psychoneuroendocrinology (1995) [Pubmed]
  34. Rat strain differences in nicotine self-administration using an unlimited access paradigm. Brower, V.G., Fu, Y., Matta, S.G., Sharp, B.M. Brain Res. (2002) [Pubmed]
  35. Hypothalamic PGE2 and cAMP production and adrenocortical activation following intraperitoneal endotoxin injection: in vivo microdialysis studies in Lewis and Fischer rats. Smith, T., Hewson, A.K., Quarrie, L., Leonard, J.P., Cuzner, M.L. Neuroendocrinology (1994) [Pubmed]
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