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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Stability and cellular responses to fluorapatite-collagen composites.

Fluorapatite (FA)-collagen composites were synthesized via a biomimetic coprecipitation method in order to improve the structural stability and cellular responses. Different amounts of ammonium fluoride (NH4F), acting as a fluorine source for FA, were added to the precipitation of the composites. The precipitated composites were freeze-dried and isostatically pressed in a dense body. The added fluorine was incorporated nearly fully into the apatite structure (fluoridation), and a near stoichiometric FA-collagen composite was obtained with complete fluoridation. The freeze-dried composites had a typical biomimetic network, consisting of collagen fibers and precipitates of nano-sized apatite crystals. The human osteoblast-like cells on the FA-collagen composites exhibited significantly higher proliferation and differentiation (according to alkaline phosphatase activity) than those on the hydroxyapatite-collagen composite. These enhanced osteoblastic cell responses were attributed to the fluorine release and the reduced dissolution rate.[1]


  1. Stability and cellular responses to fluorapatite-collagen composites. Yoon, B.H., Kim, H.W., Lee, S.H., Bae, C.J., Koh, Y.H., Kong, Y.M., Kim, H.E. Biomaterials (2005) [Pubmed]
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