Disease relevance of Biomimetics

• The most successful of these biomimetic catalysts (cysteamine) was used to encapsulate firefly luciferase, green and blue fluorescent proteins (GFP, BFP), and Escherichia coli cells expressing GFP in silica matrixes [1].
• A single application of 1% Evodia biomimetic mixture also significantly inhibited MN-induced erythema when applied at 60 min before, or within 5 min after MN exposure [2].
• Synthesis of biomimetic analogs of neomycin B: potential inhibitors of the HIV RNA Rev response element [3].

High impact information on Biomimetics

• Despite a high mineral content of about 99% (by volume) of aragonite, the shell of Strombus gigas can thus be considered a 'ceramic plywood' and can guide the biomimetic design of tough, lightweight structures [4].
• Catalytic galactose oxidase models: biomimetic Cu(II)-phenoxyl-radical reactivity [5].
• Dinitrogen coordination chemistry: on the biomimetic borderlands [6].
• Twinfilin replaces capping protein and promotes motility of N-WASP functionalized beads in a biomimetic motility assay, indicating that the capping activity supports twinfilin's function in motility [7].
• Ruthenium polypyridine complexes. On the route to biomimetic assemblies as models for the photosynthetic reaction center [8].

Biological context of Biomimetics

• Total synthesis of the quinone epoxide dimer (+)-torreyanic acid: application of a biomimetic oxidation/electrocyclization/Diels-Alder dimerization cascade [9].
• Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers [10].
• Thus, the combination of acyl phosphate esters and lanthanide salts appears to be a promising method for biomimetic acylation of hydroxyl groups [11].
• A density functional study on a biomimetic non-heme iron catalyst: insights into alkane hydroxylation by a formally HO-FeV=O oxidant [12].
• CONCLUSION: BMP-2 incorporated into biomimetic calcium phosphate coatings is capable not only of inducing bone formation at an ectopic site in vivo but also of doing so with a very high potency at a low pharmacological level, and of sustaining this activity for a considerable period of time [13].

Anatomical context of Biomimetics

• Here, we analyse the effects of T-plastin/T-fimbrin, a representative member of an important actin-filament cross-linking protein by combining a quantitative biomimetic motility assay with biochemical and cell-based approaches [14].
• Use of a biomimetic chromatographic stationary phase for study of the interactions occurring between inorganic anions and phosphatidylcholine membranes [15].
• A biomimetic model is described for the detection of adenosine triphosphate (ATP) release from red blood cells (RBCs) as they traverse fused-silica tubing ranging in i.d. from 25 to 75 microm [16].
• Quantitative assessment of hydroxyapatite formation on a gold surface via the biomimetic method, composed of a nucleation step in a simulated body fluid (SBF) containing glass powders and a subsequent apatite growth step in glass powder-free SBF, was made using a quartz crystal microbalance (QCM) technique [17].
• Human endothelial cell interaction with biomimetic surfactant polymers containing Peptide ligands from the heparin binding domain of fibronectin [18].

Associations of Biomimetics with chemical compounds

• A facile scheme by which FeMoco and alternative, non-molybdenum-containing nitrogenase cofactors are constructed from this common precursor is presented that has important implications for the biosynthesis and biomimetic chemical synthesis of FeMoco [19].
• Recent structural and spectroscopic studies on a series of biomimetic model compounds have provided new and valuable insights into the key reactive intermediates involved in the dioxygen processing at the mononuclear copper reaction centers in biological systems [20].
• Biomimetic model high-valent porphyrins showed reduction rates with variously 4-substituted N,N-dialkylanilines that were consistent with a positively charged intermediate; such relationships were not seen for anisole O-demethylation with P450 2B1 [21].
• As a first step toward the design and fabrication of biomimetic bonelike composite materials, we have developed a template-driven nucleation and mineral growth process for the high-affinity integration of hydroxyapatite with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold [22].
• Surface-initiated atom transfer radical polymerization (SI-ATRP) was performed through the adsorbed biomimetic initiator to polymerize methyl methacrylate macromonomers with oligo(ethylene glycol) (OEG) side chains [23].

Gene context of Biomimetics

• Biomimetic synthesis of the tumor-associated (2,3)-sialyl-T antigen and its incorporation into glycopeptide antigens from the mucins MUC1 and MUC4 [24].
• The generation of three-dimensional biomimetic structures incorporating osteoinductive factors such as BMP-2 indicates their potential for de novo bone formation that exploits cell-matrix interactions and, significantly, realistic delivery protocols for growth factors in musculoskeletal tissue engineering [25].
• The individual subunits did not interact with Cibacron Blue F3G-A, a biomimetic ligand of phosphofructokinase-1 [26].
• Additionally, secretin interacts with a biomimetic phospholipid membrane as indicated from a significant increase in membrane surface pressure (from 25.5 +/- 1.3 to 32.5 +/- 3.0, P < 0.05) [27].
• Owing to the large OBP-1F amounts expressed, we set up a novel biomimetic assay (volatile-odorant binding assay) to study the uptake of airborne odorants without radiolabelling and attempted to understand the odorant capture by OBP in the nasal mucus under natural conditions [28].

Analytical, diagnostic and therapeutic context of Biomimetics

• A hierarchically organized architecture in multiple scales was generated from potassium hydrogen phthalate crystals and poly(acrylic acid) based on our novel biomimetic approach with an exquisite association of polymers on crystallization [29].
• Scanning electron microscopy (SEM) confirmed that gelatin impregnation of the graft followed by the subsequent biomimetic film coating filled in the fibril and node structure of the luminal surface of the ePTFE graft and was smooth [30].
• The study of nanogel (hydrogel nanoparticle) has intensified in the last decade due to the enormous potential applications in biomimetics, biosensors, artificial muscles and drug delivery (or release) systems [31].
• The studies suggest that the ABM/P-15 in hydrogels can be used as an injectable biomimetic matrix to facilitate bone repair [32].
• Two natural macromolecules, chitosan and gelatin, were tethered on these nanofibrous membranes to fabricate dual-layer biomimetic supports for enzyme immobilization in the presence of 1-ethyl-3-(dimethyl-aminopropyl) carbodiimide hydrochloride (EDC)/N-hydroxyl succinimide (NHS) [33].

References