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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium.

The antihepatotoxic activity of elaterium (dried juice of the fruits of Ecballium elaterium, Cucurbitaceae) and cucurbitacin B (isolated from the juice) was studied against CCl4-induced hepatotoxicity. Pre- and posttreatment with elaterium and cucurbitacin B reduced CCl4-hepatotoxicity, as shown reduction in the anormally increased sGPT levels. Posttreatment caused a significant reduction in the degree of steatosis observed inthe control group, treated only with CCl4. In conclusion, elaterium and cucurbitacin B had preventive and curative effects against CCl4-induced hepatotoxicity.[1]


  1. Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium. Agil, A., Miró, M., Jimenez, J., Aneiros, J., Caracuel, M.D., García-Granados, A., Navarro, M.C. Planta Med. (1999) [Pubmed]
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