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Disease relevance of Cucurbitaceae


High impact information on Cucurbitaceae

  • The diabroticite rootworm beetles coevolved with plants of the family Cucurbitaceae as demonstrated by their feeding dependence on the tetracyclic triterpenoid cucurbitacins [2].
  • Extracts from Gynostemma pentaphyllum Makino (Cucurbitaceae), a Southeast Asian herb, has been reported to affect numerous activities resulting in antitumor, cholesterol-lowering, immunopotentiating, antioxidant, and hypoglycemic effects [3].
  • The crystal structure of the complex formed by porcine beta-trypsin with the MCTI-A inhibitor (Momordica charantia, Linn. Cucurbitaceae) has been determined at 1.6 A resolution using the molecular replacement method [4].
  • Bryonia dioica (Cucurbitaceae family) produces at least two type I ribosome-inactivating proteins, bryodin 1 (BD1) and bryodin 2 (BD2) [5].
  • As tubeimoside I isolated from Bolbostemma paniculatum (Maxim.) Franquet (Cucurbitaceae) has been shown to suppress tumor promoter effects, tubeimoside III from the same plant was tested in vitro and in vivo against the action of the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) [6].

Biological context of Cucurbitaceae


Associations of Cucurbitaceae with chemical compounds


Gene context of Cucurbitaceae

  • A 7514-Da chymotrypsin inhibitor was isolated from the seed extract of Momordica cochinchinensis (Family Cucurbitaceae) by chromatography on chymotrypsin-Sepharose 4B and subsequently by C18 reversed-phase HPLC [12].
  • Olean-12-enol (16), isomultiflorenol (8), and lupeol (23) were the dominant alcohols in the Cucurbitaceae family, whereas alpha-amyrin (urs-12-enol) (20) was the dominant triterpene alcohol in ATF and MNT [13].
  • Unlike glucose-6-phosphatase, starvation induced levels of gluconeogenic enzymes alanine aminotransferase and aspartate aminotransferase were not affected by Coccinia extract [14].
  • Anti-inflammatory efficacy of Melothria madraspatana in active rheumatoid arthritis [15].
  • The synthesis of a 28-residue peptide isolated from Ecballium elaterium of the Cucurbitaceae family which strongly inhibits trypsin activities (Ka = 8.10(-11)M), using BOP as the coupling reagent in a solid phase procedure is presented [16].


  1. Effect of Coccinia indica leaves on antioxidant status in streptozotocin-induced diabetic rats. Venkateswaran, S., Pari, L. Journal of ethnopharmacology. (2003) [Pubmed]
  2. Evolution of diabroticite rootworm beetle (Chrysomelidae) receptors for Cucurbita blossom volatiles. Metcalf, R.L., Lampman, R.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. A novel insulin-releasing substance, phanoside, from the plant Gynostemma pentaphyllum. Norberg, A., Hoa, N.K., Liepinsh, E., Van Phan, D., Thuan, N.D., Jörnvall, H., Sillard, R., Ostenson, C.G. J. Biol. Chem. (2004) [Pubmed]
  4. Refined 1.6 A resolution crystal structure of the complex formed between porcine beta-trypsin and MCTI-A, a trypsin inhibitor of the squash family. Detailed comparison with bovine beta-trypsin and its complex. Huang, Q., Liu, S., Tang, Y. J. Mol. Biol. (1993) [Pubmed]
  5. Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a ribosome-inactivating protein from the plant Bryonia dioica. Gawlak, S.L., Neubauer, M., Klei, H.E., Chang, C.Y., Einspahr, H.M., Siegall, C.B. Biochemistry (1997) [Pubmed]
  6. Inhibition of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by tubeimoside III isolated from Bolbostemma paniculatum. Yu, L., Yu, T., Ma, R. Carcinogenesis (1995) [Pubmed]
  7. GC balance in the internal transcribed spacers ITS 1 and ITS 2 of nuclear ribosomal RNA genes. Torres, R.A., Ganal, M., Hemleben, V. J. Mol. Evol. (1990) [Pubmed]
  8. Hypoglycaemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Shibib, B.A., Khan, L.A., Rahman, R. Biochem. J. (1993) [Pubmed]
  9. Macluralisin--a serine proteinase from fruits of Maclura pomifera (Raf.) Schneid. Rudenskaya, G.N., Bogdanova, E.A., Revina, L.P., Golovkin, B.N., Stepanov, V.M. Planta (1995) [Pubmed]
  10. Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium. Agil, A., Miró, M., Jimenez, J., Aneiros, J., Caracuel, M.D., García-Granados, A., Navarro, M.C. Planta Med. (1999) [Pubmed]
  11. Anti-allergic effect of bryonolic acid from Luffa cylindrica cell suspension cultures. Tanaka, S., Uno, C., Akimoto, M., Tabata, M., Honda, C., Kamisako, W. Planta Med. (1991) [Pubmed]
  12. First report on a potato I family chymotrypsin inhibitor from the seeds of a Cucurbitaceous plant, Momordica cochinchinensis. Tsoi, A.Y., Wong, R.C., Ng, T.B., Fong, W.P. Biol. Chem. (2004) [Pubmed]
  13. Unsaponifiable lipid constituents of some underutilized tropical seed oils. Esuoso, K.O., Lutz, H., Bayer, E., Kutubuddin, M. J. Agric. Food Chem. (2000) [Pubmed]
  14. Hypoglycemic effects of Coccinia indica: inhibition of key gluconeogenic enzyme, glucose-6-phosphatase. Hossain, M.Z., Shibib, B.A., Rahman, R. Indian J. Exp. Biol. (1992) [Pubmed]
  15. Anti-inflammatory efficacy of Melothria madraspatana in active rheumatoid arthritis. Ramakrishanamacharya, C.H., Krishnaswamy, M.R., Rao, R.B., Viswanathan, S. Clin. Rheumatol. (1996) [Pubmed]
  16. Solid phase synthesis of a trypsin inhibitor isolated from the Cucurbitaceae Ecballium elaterium. Le-Nguyen, D., Nalis, D., Castro, B. Int. J. Pept. Protein Res. (1989) [Pubmed]
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