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Chemical Compound Review

AC1L47RC     [(6R)-6-[ (2S,8S,9R,10S,13R,14S,16R,17S) -2...

Synonyms: NCI60_004184
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  • The subfraction (F-III) from CH2Cl2 extract and compounds isolated as cucurbitacin B and E also inhibited carrageenan-induced edema [1].

High impact information on CUCURBITACIN R - DATISCA PRINCIPLE B

  • Cucurbitacin B (cucB) prevents stimulation by 20E of an ecdysteroid-responsive reporter gene in a transfection assay [2].
  • A new sulfated cucurbitacin, cucurbitacin B 2-sulfate (1) and a new cucurbitacin glucoside, cucurbitacin G 2-O-beta-D-glucopyranoside (2) together with two known cucurbitacin glucosides, arvenin I and arvenin III were isolated from the root bark of Helicteres angustifolia [3].
  • Cucurbitacin B 2-Sulfate and Cucurbitacin Glucosides from the Root Bark of Helicteres angustifolia [3].
  • Cucurbitacin B (1) imparts a bitter taste to the flesh of the fungus; however, it occurs in the fruiting bodies mainly esterified as tasteless fatty acid esters 2a-c. In vitro growth inhibitory effects of compounds 1-4 on proliferation of four different human tumor cell lines (A549, CAKI-1, HepG2, MCF-7) were evaluated by using a 1-day MTT assay [4].
  • The F-DCM was also able to prevent PGE2 formation in exsudate leakage induced by carrageenan, as well as Cucurbitacin B, its active principle [5].


  1. Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata. Peters, R.R., Farias, M.R., Ribeiro-do-Valle, R.M. Planta Med. (1997) [Pubmed]
  2. Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. Dinan, L., Whiting, P., Girault, J.P., Lafont, R., Dhadialla, T.S., Cress, D.E., Mugat, B., Antoniewski, C., Lepesant, J.A. Biochem. J. (1997) [Pubmed]
  3. Cucurbitacin B 2-Sulfate and Cucurbitacin Glucosides from the Root Bark of Helicteres angustifolia. Chen, Z.T., Lee, S.W., Chen, C.M. Chem. Pharm. Bull. (2006) [Pubmed]
  4. Cucurbitane triterpenoids from Leucopaxillus gentianeus. Clericuzio, M., Mella, M., Vita-Finzi, P., Zema, M., Vidari, G. J. Nat. Prod. (2004) [Pubmed]
  5. Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice. Peters, R.R., Saleh, T.F., Lora, M., Patry, C., de Brum-Fernandes, A.J., Farias, M.R., Ribeiro-do-Valle, R.M. Life Sci. (1999) [Pubmed]
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