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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens.

A new 4alpha-aryltetralin-type lignan called burseranin (1) and a known analogous lignan picropolygamain (2) were isolated along with known triterpenes, lupeol and epi-lupeol from the methanol extract of stems of Bursera graveolens, which showed a remarkable inhibitory activity against human HT1080 fibrosarcoma cells. The whole structure of 1 was established based on combined spectral studies and the absolute structure for 2 was first confirmed by CD spectral evidence. In addition, cytotoxic activities of the stem (methanol) extract and its components are evaluated in this paper.[1]


  1. A new and known cytotoxic aryltetralin-type lignans from stems of Bursera graveolens. Nakanishi, T., Inatomi, Y., Murata, H., Shigeta, K., Iida, N., Inada, A., Murata, J., Farrera, M.A., Iinuma, M., Tanaka, T., Tajima, S., Oku, N. Chem. Pharm. Bull. (2005) [Pubmed]
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