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MeSH Review


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Disease relevance of Fibrosarcoma


High impact information on Fibrosarcoma


Chemical compound and disease context of Fibrosarcoma


Biological context of Fibrosarcoma


Anatomical context of Fibrosarcoma


Gene context of Fibrosarcoma

  • RESULTS: A variety of drug-resistant human cancer cell lines derived by selection with mitoxantrone markedly overexpressed BCRP mRNA; these cell lines included sublines of human breast carcinoma (MCF-7), colon carcinoma (S1 and HT29), gastric carcinoma (EPG85-257), fibrosarcoma (EPF86-079), and myeloma (8226) origins [25].
  • Three of these tumours, a T-cell lymphoma, a fibrosarcoma and a macrophage tumour, were found to carry an activated c-Ki-ras gene [26].
  • HFKs, HT1080 fibrosarcoma and QG56 cells, as well as many other human cells, contain varying ratios of GP90 and structurally related, higher molecular mass forms of CD44 that express the following characteristics: (a) each form reacted with anti-CD44 (mAbs) P1G12, P3H9, and P3H5 [27].
  • Human TCP1 cDNA clones from both fibrosarcoma and B cell lines confirmed that there was a single expressed gene. mRNA transcripts of different sizes were accounted for by two different polyadenylation signals [28].
  • The E-26 transforming specific (ETS)-related gene TEL, also known as ETV6, is involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma [29].

Analytical, diagnostic and therapeutic context of Fibrosarcoma


  1. MSA and EGF receptors on sarcoma virus transformed cells and human fibrosarcoma cells in culture. Todaro, G.J., De Larco, J.E., Nissley, S.P., Rechler, M.M. Nature (1977) [Pubmed]
  2. Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor. Dong, Z., Yoneda, J., Kumar, R., Fidler, I.J. J. Exp. Med. (1998) [Pubmed]
  3. A transformation-associated 130-kD cell surface glycoprotein is growth controlled in normal human cells. Klein, C.E., Ozer, H.L., Traganos, F., Atzpodien, J., Oettgen, H.F., Old, L.J. J. Exp. Med. (1988) [Pubmed]
  4. Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection. Routes, J.M., Ryan, S., Morris, K., Takaki, R., Cerwenka, A., Lanier, L.L. J. Exp. Med. (2005) [Pubmed]
  5. Isolation of the thrombospondin membrane receptor. Asch, A.S., Barnwell, J., Silverstein, R.L., Nachman, R.L. J. Clin. Invest. (1987) [Pubmed]
  6. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Knezevich, S.R., McFadden, D.E., Tao, W., Lim, J.F., Sorensen, P.H. Nat. Genet. (1998) [Pubmed]
  7. Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma. Kandel, J., Bossy-Wetzel, E., Radvanyi, F., Klagsbrun, M., Folkman, J., Hanahan, D. Cell (1991) [Pubmed]
  8. Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells. Paterson, H., Reeves, B., Brown, R., Hall, A., Furth, M., Bos, J., Jones, P., Marshall, C. Cell (1987) [Pubmed]
  9. Regulation of fibronectin biosynthesis by glucocorticoids in human fibrosarcoma cells and normal fibroblasts. Oliver, N., Newby, R.F., Furcht, L.T., Bourgeois, S. Cell (1983) [Pubmed]
  10. Regulation of prostaglandin synthesis mediated by thrombin and B2 bradykinin receptors in a fibrosarcoma cell line. Becherer, P.R., Mertz, L.F., Baenziger, N.L. Cell (1982) [Pubmed]
  11. Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells. Tashjian, A.H., Voelkel, E.F., McDonough, J., Levine, L. Nature (1975) [Pubmed]
  12. Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas. Nawroth, P., Handley, D., Matsueda, G., De Waal, R., Gerlach, H., Blohm, D., Stern, D. J. Exp. Med. (1988) [Pubmed]
  13. Low-dose cyclophosphamide inhibition of transplantable fibrosarcoma growth by augmentation of the host immune response. Ray, P.K., Raychaudhuri, S. J. Natl. Cancer Inst. (1981) [Pubmed]
  14. Effect of various oxygenation conditions and fluosol-DA on cytotoxicity and antitumor activity of bleomycin in mice. Teicher, B.A., Holden, S.A., Cathcart, K.N., Herman, T.S. J. Natl. Cancer Inst. (1988) [Pubmed]
  15. Dietary menhaden oil lowers plasma prostaglandins and calcium in mice bearing the prostaglandin-producing HSDM1 fibrosarcoma. Tashjian, A.H., Voelkel, E.F., Robinson, D.R., Levine, L. J. Clin. Invest. (1984) [Pubmed]
  16. Failure of wild-type or a mutant form of protein kinase C-alpha to transform fibroblasts. Borner, C., Filipuzzi, I., Weinstein, I.B., Imber, R. Nature (1991) [Pubmed]
  17. Frequent activation of c-kis as a transforming gene in fibrosarcomas induced by methylcholanthrene. Eva, A., Aaronson, S.A. Science (1983) [Pubmed]
  18. Plasminogen activator inhibitor 1 and 2 are tumor necrosis factor/cachectin-responsive genes. Medcalf, R.L., Kruithof, E.K., Schleuning, W.D. J. Exp. Med. (1988) [Pubmed]
  19. Effect of cyclin D1 overexpression on drug sensitivity in a human fibrosarcoma cell line. Hochhauser, D., Schnieders, B., Ercikan-Abali, E., Gorlick, R., Muise-Helmericks, R., Li, W.W., Fan, J., Banerjee, D., Bertino, J.R. J. Natl. Cancer Inst. (1996) [Pubmed]
  20. Down-regulation of murine fibrosarcoma transforming growth factor-beta 1 expression by interleukin 7. Dubinett, S.M., Huang, M., Dhanani, S., Economou, J.S., Wang, J., Lee, P., Sharma, S., Dougherty, G.J., McBride, W.H. J. Natl. Cancer Inst. (1995) [Pubmed]
  21. Tumor cell invasion inhibited by TIMP-2. Albini, A., Melchiori, A., Santi, L., Liotta, L.A., Brown, P.D., Stetler-Stevenson, W.G. J. Natl. Cancer Inst. (1991) [Pubmed]
  22. Inhibition by bovine endothelial cells of degradation by HT-1080 fibrosarcoma cells of extracellular matrix proteins. Heisel, M., Laug, W.E., Jones, P.A. J. Natl. Cancer Inst. (1983) [Pubmed]
  23. Noncytolytic extraction of murine tumor-specific transplantation antigens with the nonionic detergent octyl-beta-D-glucopyranoside. LeGrue, S.J., Macek, C.M., Kahan, B.D. J. Natl. Cancer Inst. (1982) [Pubmed]
  24. Pericytes limit tumor cell metastasis. Xian, X., Håkansson, J., Ståhlberg, A., Lindblom, P., Betsholtz, C., Gerhardt, H., Semb, H. J. Clin. Invest. (2006) [Pubmed]
  25. Atypical multidrug resistance: breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines. Ross, D.D., Yang, W., Abruzzo, L.V., Dalton, W.S., Schneider, E., Lage, H., Dietel, M., Greenberger, L., Cole, S.P., Doyle, L.A. J. Natl. Cancer Inst. (1999) [Pubmed]
  26. Three different activated ras genes in mouse tumours; evidence for oncogene activation during progression of a mouse lymphoma. Vousden, K.H., Marshall, C.J. EMBO J. (1984) [Pubmed]
  27. Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons. Brown, T.A., Bouchard, T., St John, T., Wayner, E., Carter, W.G. J. Cell Biol. (1991) [Pubmed]
  28. The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region. Willison, K., Kelly, A., Dudley, K., Goodfellow, P., Spurr, N., Groves, V., Gorman, P., Sheer, D., Trowsdale, J. EMBO J. (1987) [Pubmed]
  29. Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. Chakrabarti, S.R., Sood, R., Ganguly, S., Bohlander, S., Shen, Z., Nucifora, G. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  30. Pentoxifylline inhibits interleukin-2-induced toxicity in C57BL/6 mice but preserves antitumor efficacy. Edwards, M.J., Heniford, B.T., Klar, E.A., Doak, K.W., Miller, F.N. J. Clin. Invest. (1992) [Pubmed]
  31. Localization of radiolabeled monoclonal antibody in a human soft tissue sarcoma xenograft. Brown, J.M., Greager, J.A., Pavel, D.G., Gupta, T.K. J. Natl. Cancer Inst. (1985) [Pubmed]
  32. Augmentation of tumor immunity against syngeneic tumors in mice by beta-carotene. Tomita, Y., Himeno, K., Nomoto, K., Endo, H., Hirohata, T. J. Natl. Cancer Inst. (1987) [Pubmed]
  33. Metastatic behavior of the RIF-1 murine fibrosarcoma: inhibited by hypophysectomy and partially restored by growth hormone replacement. Sekyi-Otu, A., Bell, R., Andrulis, I., Pollak, M. J. Natl. Cancer Inst. (1994) [Pubmed]
  34. Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography. Neufeld, E.J., Majerus, P.W., Krueger, C.M., Saffitz, J.E. J. Cell Biol. (1985) [Pubmed]
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