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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae.

We report the isolation of a cDNA (KAT1) from Arabidopsis thaliana that encodes a probable K+ channel. KAT1 was cloned by its ability to suppress a K+ transport-defective phenotype in mutant Saccharomyces cerevisiae cells. This suppression is sensitive to known K+ channel blockers, including tetraethylammonium and Ba2+ ions. The KAT1 cDNA contains an open reading frame capable of encoding a 78-kDa protein that shares structural features found in the Shaker superfamily of K+ channels. These include a cluster of six putative membrane-spanning helices (S1-S6) at the amino terminus of the protein, a presumed voltage-sensing region containing Arg/Lys-Xaa-Xaa-Arg/Lys repeats within S4, and the highly conserved pore-forming region (known as H5 or SS1- SS2). Our results suggest that the structural motif for K+ channels has been conserved between plants and animals.[1]

References

  1. Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae. Anderson, J.A., Huprikar, S.S., Kochian, L.V., Lucas, W.J., Gaber, R.F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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